Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats.

Hypertension
Misa YoshimotoJohn W Osborn

Abstract

Angiotensin II (AngII)-induced hypertension in experimental animals has been proposed to be attributed in part to activation of the sympathetic nervous system. This sympathetic activation appears to be accentuated in animals consuming a high-salt diet (AngII-salt hypertension). However, accurate quantification of sympathetic activity is difficult, and controversy remains. It is particularly important to ask which are the critical vascular beds targeted by increased sympathetic nerve activity (SNA) in AngII-salt hypertension. To address this issue, mean arterial pressure and renal SNA or lumbar SNA were continuously recorded during a 5-day control period, 11 days of AngII (150 ng/kg per minute, SC), and a 5-day recovery period in conscious rats on a high-salt (2% NaCl) diet. Although mean arterial pressure reached a new steady-state level of 30 to 35 mm Hg above control levels by the end of the AngII period, renal SNA decreased by 40% during the first 7 days of AngII and then returned toward control levels by day 10 of AngII. In contrast, lumbar SNA remained at control levels throughout the AngII period. In another experiment we measured hindlimb norepinephrine spillover in conscious rats on normal (0.4%) or high- (2.0%) salt di...Continue Reading

References

Oct 1, 1991·The American Journal of Physiology·B F Cox, V S Bishop
Aug 2, 1990·European Journal of Pharmacology·R L KlineP F Mercer
Nov 1, 1983·Hypertension·C M Ferrario
Jan 1, 1980·Annual Review of Physiology·M J BrodyK B Touw
Feb 7, 1998·Hypertension·T E Lohmeier, D A Hildebrandt
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ling Xu, Alan F Sved
Jul 17, 2003·Journal of Neuroscience Methods·Sandra L Burke, Geoffrey A Head
Mar 17, 2004·The Journal of Physiology·Kenju MikiMisa Yoshimoto
Jul 21, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Graeme Eisenhofer
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
May 24, 2007·Current Hypertension Reports·John W OsbornMohan K Raizada
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew J KingGregory D Fink
Oct 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Misa YoshimotoJohn W Osborn
Aug 25, 2009·Experimental Physiology·Sarah-Jane GuildSimon C Malpas

❮ Previous
Next ❯

Citations

Mar 2, 2011·Current Hypertension Reports·Sandra L BurkeGeoffrey A Head
May 18, 2013·Current Hypertension Reports·Rohit RamchandraClive N May
Sep 21, 2013·Current Hypertension Reports·Sean D StockerKirsteen N Browning
May 23, 2012·The Journal of Physiological Sciences : JPS·Masami Iriki, Eckhart Simon
Aug 25, 2011·American Journal of Physiology. Endocrinology and Metabolism·Annette D de KloetStephen C Woods
Nov 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Marcos T KurokiJohn W Osborn
Feb 25, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick J MuellerTadeusz J Scislo
Oct 8, 2011·Journal of Applied Physiology·Nicholas A Mischel, Patrick J Mueller
Mar 12, 2013·Autonomic Neuroscience : Basic & Clinical·M J Kenney, L J Mosher
Sep 6, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sachin S Kandlikar, Gregory D Fink
Aug 3, 2010·Respiratory Physiology & Neurobiology·A E SimmsA E Pickering
Mar 10, 2016·Current Hypertension Reports·Chansol Hurr, Colin N Young
Oct 5, 2011·Experimental Physiology·John W OsbornGregory D Fink
Aug 13, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J A N DorresteijnW Spiering
Sep 22, 2015·Frontiers in Physiology·Rohit Ramchandra, Carolyn J Barrett
Dec 23, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katelynn FaulkJ Thomas Cunningham
Apr 2, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartJohn W Osborn
May 4, 2011·Hypertension·Jasenka ZubcevicJulian F R Paton
Sep 13, 2018·Bioscience Reports·Christopher J CharlesA Mark Richards
Oct 15, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Gustavo R PedrinoGlenn M Toney
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert FrithiofRohit Ramchandra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.