PMID: 48901Jun 7, 1975Paper

Chronic antigenic stimulation, herpesvirus infection, and cancer in transplant recipients

Lancet
A J MatasJ S Najarian

Abstract

An increased incidence of malignancy has been reported in transplant recipients. The pathogenesis of this increase was originally attributed to immunosuppressive therapy. However, not all tumours are increased in proportion to their occurrence in the general population-75% of reported tumours are lymphorproliferative or carcinoma of the skin, lip, or cervix. This cannot be explained by impaired immunosurveillance, and alternative hypotheses must be considered. 90% of transplant recipients develop clinical or serological evidence of herpesvirus infection. Herpesviruses have been implicated in the pathogenesis of lymphorproliferative tumours and carcinoma of the skin and cervix. They can remain in latent form and be reactivated by allogeneic stimulation and/or immunosuppression. These viruses localise to skin, cervix, and neural tissue-i.e., exactly those sites where cancer develops in transplant patients. Herpesvirus infections in association with the presence of an allogeneic graft in an immunosuppressed patient may be responsible for the increased incidence of both lymphoproliferative tumours and carcinoma of the skin, lip, and cervix in the transplant recipient.

References

Feb 20, 1975·The New England Journal of Medicine·C GroseP M Feorino
Jan 2, 1975·The New England Journal of Medicine·R J Lukes, B H Tindle
Jul 14, 1973·Lancet·R Hoover, J F Fraumeni
Dec 1, 1971·The Journal of Hygiene·J Nagington
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·G Klein
Oct 20, 1972·Science·F O BastianT S Tralka
Mar 29, 1973·The New England Journal of Medicine·J R Baringer, P Swoveland
May 4, 1973·Science·M S HirschM L Wood
Mar 1, 1974·The American Journal of Medicine·C LopezS Gentry
Oct 17, 1974·The New England Journal of Medicine·J R Baringer
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M S HirschC B Carpenter
Dec 1, 1973·The Australian and New Zealand Journal of Surgery·V C Marshall
May 15, 1969·International Journal of Cancer. Journal International Du Cancer·J H PopeW Scott
Nov 5, 1955·British Medical Journal·R WYBURN-MASON
Sep 14, 1957·British Medical Journal·R WYBURN-MASON
Feb 1, 1961·Medicine·S A ROSENBERGL F CRAVER
Sep 1, 1959·The Journal of Infectious Diseases·S A ELLISONH M ROSE
Feb 1, 1962·The American Journal of Medicine·J RICHMONDL F CRAVER

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Citations

Jul 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·M HüfnerM Ntokalou
Jul 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·B HöffkenR D Hesch
Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·N BlomqvistJ Wålinder
May 2, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Hüfner, M Grussendorf
Jan 1, 1976·Journal of Biological Standardization·A F GarrettD E Reeson
Jan 1, 1992·Toxicology·B Ryffel
Dec 5, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Paul V KeoghStephen R Flint
Feb 19, 1977·British Medical Journal·R Y Calne, R Williams
Oct 25, 1986·British Medical Journal·C G Semple
Feb 1, 1983·Postgraduate Medical Journal·B P Gardner, D B Evans
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ashokkumar JainJohn Fung
Jul 3, 2013·Clinical Transplantation·Hemant ChatrathMarwan Ghabril
Feb 1, 1990·Surgical Neurology·F SlowikJ Hável
Jan 1, 1983·Clinical and Experimental Dialysis and Apheresis·H InamotoA Osawa
Apr 1, 1982·Current Problems in Cancer·I Penn
Jun 5, 2002·Nature Reviews. Cancer·Chris Boshoff, Robin Weiss
Jan 1, 1992·Drug and Chemical Toxicology·B RyffelG L Fisher
Jan 1, 1978·Cancer·J M MooyJ M van Turnhout
Sep 11, 2009·Transplantation·Ashokkumar JainMark Orloff
Sep 1, 1979·The Journal of Urology·J E Montie
Aug 1, 1978·European Journal of Clinical Investigation·W WeimarP De Somer
Jun 9, 2009·Anais Brasileiros De Dermatologia·Sylvia Ypiranga, Aparecida Machado de Moraes

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