Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis

Intensive Care Medicine
Maryse A WiewelMARS Consortium

Abstract

Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of sepsis, and the host response. We performed a prospective observational study in 972 patients admitted with sepsis to the mixed intensive care units (ICUs) of two hospitals in the Netherlands between January 2011 and July 2013. Of them, 267 patients (27.5%) were on antiplatelet therapy (95.9% acetylsalicylic acid) before admission. To account for differential likelihoods of receiving antiplatelet therapy, a propensity score was constructed, including variables associated with use of antiplatelet therapy. Cox proportional hazards regression was used to estimate the association of antiplatelet therapy with mortality. Antiplatelet therapy was not associated with sepsis severity at presentation, the primary source of infection, causative pathogens, the development of organ failure or shock during ICU stay, or mortality up to 90 days after admission, in either unmatched or propensity-matched analyses. Antiplatelet therapy did not ...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Jul 9, 2005·Critical Care Medicine·Thierry CalandraUNKNOWN International Sepsis Forum Definition of Infection in the ICU Consensus Conference
Dec 27, 2005·Best Practice & Research. Clinical Haematology·Marcel LeviTom van der Poll
Feb 22, 2007·Current Neurovascular Research·Ali Al-BahraniMoiz Bakhiet
Nov 23, 2007·Journal of Leukocyte Biology·Marcel SchoutenTom van der Poll
Apr 16, 2009·Clinical Microbiology Reviews·Ineke Vanlaere, Claude Libert
Dec 17, 2009·Cellular and Molecular Life Sciences : CMLS·Michael R Yeaman
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Oct 12, 2010·Lancet·Neill K J AdhikariGordon D Rubenfeld
Mar 26, 2011·Nature Reviews. Immunology·John W SempleJohn Freedman
Jan 9, 2013·Critical Care : the Official Journal of the Critical Care Forum·Maik SossdorfWolfgang Lösche
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Sep 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sif GudbrandsdottirClaus H Nielsen
Oct 10, 2013·Thrombosis Research·Karolina Akinosoglou, Dimitrios Alexopoulos
Oct 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jillian StephenIan Dransfield
Feb 7, 2014·American Journal of Respiratory and Critical Care Medicine·Peter M C Klein KlouwenbergUNKNOWN MARS Consortium
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
Jun 27, 2014·Thrombosis and Haemostasis·Sacha F de StoppelaarTom van der Poll
Jun 30, 2015·American Journal of Respiratory and Critical Care Medicine·Brendon P SciclunaTom van der Poll
Sep 9, 2015·Critical Care : the Official Journal of the Critical Care Forum·Peter M C Klein KlouwenbergTom van der Poll

❮ Previous
Next ❯

Citations

Feb 14, 2016·Intensive Care Medicine·Min-Juei TsaiYung-Tai Chen
Jan 13, 2017·Critical Care Medicine·Maryse A WiewelUNKNOWN Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium
Oct 21, 2017·International Journal of Molecular Sciences·Elisabetta GrecoGiuseppe Montrucchio
Jan 20, 2018·Annals of Intensive Care·Maryse A WiewelTom van der Poll
Aug 29, 2020·Journal of Cardiovascular Medicine·Silvia FrattiniGian B Danzi
Mar 1, 2017·International Journal of Molecular Sciences·Christa BuechlerCharalampos Aslanidis
Oct 31, 2019·Intensive Care Medicine Experimental·Laura R A SchoutenUNKNOWN MARS consortium
Apr 25, 2020·International Journal of Molecular Sciences·Aitana Braza-BoïlsManuel Mayr
Aug 28, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Yannick RabouelBeatrice Hechler
Nov 10, 2021·Journal of Thrombosis and Haemostasis : JTH·Yannick RabouëlBeatrice Hechler

❮ Previous
Next ❯

Methods Mentioned

BETA
blood drawn

Clinical Trials Mentioned

NCT01905033

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Michel Georges Dos Santos El HalalPaulo Roberto Antonacci Carvalho
Critical Care : the Official Journal of the Critical Care Forum
Peter M C Klein KlouwenbergTom van der Poll
© 2022 Meta ULC. All rights reserved