Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma

European Journal of Clinical Investigation
A S BarbasS S Lin

Abstract

Chronic aspiration associated with gastro oesophageal reflux disease (GERD) is thought to play a substantial role in the development of asthma, the incidence of which is dramatically increasing in industrially developed countries. The majority of data examining the association between aspiration and asthma has been obtained from epidemiological studies, which show that between 50 and 90% of individuals with asthma experience some element of GERD. This study describes the effect of chronic aspiration on a model of experimentally induced airway hypersensitivity in Balb/c mice. Four experimental groups were utilized: Aspiration/Asthma, Sham/Asthma, Aspiration/Sham and Sham/Sham. Mice were sensitized with aerosolized 1% ovalbumin on days 1 to 10 (sensitization phase), followed by repeated exposure on days 31 to 40 (challenge phase). Aspiration events occurred on days 1, 8,15, 22, 29, 36, 43 and 50. Animals were sacrificed on days 56 and 57. Chronic aspiration of 10 microL of murine gastric fluid per week for eight weeks produced an injury pattern distinct from that of acute aspiration, with lung injury characterized by hyperplasia, neutrophil infiltration of the bronchioles and relative parenchymal sparing. Aspiration during induct...Continue Reading

References

Dec 6, 1976·JAMA : the Journal of the American Medical Association·E E Mays
Feb 25, 2000·International Archives of Allergy and Immunology·U Neuhaus-SteinmetzH Renz
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Demetrios S TheodoropoulosStilianos E Efstratiadis
Dec 4, 2004·Alimentary Pharmacology & Therapeutics·B C Delaney
Aug 3, 2005·Archives of Pediatrics & Adolescent Medicine·Chandan SahaGilbert Liu
Jan 10, 2006·The Journal of Thoracic and Cardiovascular Surgery·Matthew G HartwigR Duane Davis
Nov 28, 2007·Journal of Tropical Pediatrics·Suna AsilsoyDilek Tezcan

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Citations

May 9, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kuei-Ying SuShu S Lin
Nov 17, 2009·Surgical Endoscopy·Anitra D ThomasShu S Lin
Dec 29, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yun LiShan-shan Wang
Apr 14, 2012·Acta Oto-laryngologica·Renzo MoraGiorgio Peretti
Oct 1, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Li Li LinShou Chuan Wang
Sep 8, 2009·Risk Analysis : an Official Publication of the Society for Risk Analysis·Ozgecan S UlusçuIlhan Or

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