Chronic AT1 receptor blockade alters aortic nerve activity in hypertension

Hypertension
C M dos SantosL C Michelini

Abstract

In the chronic phase of coarctation hypertension (CH) we have shown both reduction in baroreceptor sensitivity (Hypertension. 1992;19[suppl II]:II-198-II-201.) and normalization of the depressed baroreceptor reflex control of heart rate, even with the persistence of hypertension in losartan-treated animals (Am J Physiol. 1995;269:H812-H818). In the present study we analyzed the effects of angiotensin II blockade on afferent aortic nerve activity of CH and sham-operated groups treated chronically with vehicle or losartan (10 mg/kg per day p.o.). CH was induced by subdiaphragmatic aortic coarctation, and the treatments lasted 8 days (4 control and 4 experimental days). Aortic pressure (conscious rats) and aortic nerve activity simultaneous to pressure (anesthetized rats) were recorded on the fourth day of the experimental period. Losartan-treated rats showed reduced tail pressure (104+/-3 versus 117+/-3 mm Hg in the vehicle group). In both groups, aortic coarctation caused a significant increase in pressure (25% and 28%, respectively) and a depression of the aortic nerve activity/pressure relationship when compared with sham-operated coarcted animals. In the physiological range of pressure changes, the depression was significantl...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·B BunnemannD Ganten
Jan 1, 1992·Journal of Cardiovascular Pharmacology·U SteckelingsT Unger
Jan 1, 1992·Journal of Cardiovascular Pharmacology·P R Saxena
Feb 22, 1992·The Journal of Comparative Neurology·K SongF A Mendelsohn
May 1, 1992·Neuroendocrinology·B P RoweR C Speth
Aug 1, 1988·Journal of Hypertension·E D MoreiraE M Krieger
Feb 1, 1988·Hypertension·M J Campagnole-SantosC M Ferrario
Oct 1, 1986·Brain Research Bulletin·D I DizC M Ferrario
Feb 1, 1986·The American Journal of Physiology·R Casto, M I Phillips

❮ Previous
Next ❯

Citations

May 14, 1999·Trends in Endocrinology and Metabolism : TEM·M DodicM Wintour
Apr 7, 2007·American Journal of Therapeutics·Anita IsraelMaria del Rosario Garrido
Nov 30, 2012·International Journal of Hypertension·Bianca P CampagnaroElisardo C Vasquez
Apr 25, 2006·Autonomic Neuroscience : Basic & Clinical·Anita IsraelMaria del Rosario Garrido
Jun 2, 2005·Regulatory Peptides·José Márcio RibeiroEduardo Moacyr Krieger
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takayuki SatoKenji Sunagawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.