Abstract
To investigate the abnormalities of the upper gastrointestinal tract in liver transplant (LT) recipients, especially the prevalence of Helicobacter pylori infection and the incidence of chronic atrophic gastritis (CAG), and to explore the efficacy and safety of H pylori eradication treatment. Endoscopic screening was performed prospectively on LT recipients who received regular follow-up in our center. A group of healthy subjects with same age and sex was selected as a control group at a ratio of 1:3 with propensity score matching. All H pylori-positive recipients received Bismuth-containing quadruple therapy (esomeprazole 20 mg + clarithromycin 500 mg + amoxicillin 1 g + bismuth 220 mg, all of the medicines were applied twice daily, for 14 days). The prevalence of H pylori infection was significantly lower in LT group than control group [12/102 (11.8%) vs 98/306 (32.0%), P < .001], whereas the prevalence of CAG was similar between the two groups [48/102 (47.1%) vs 138/306 (45.1%), P = .731]. Meanwhile, the incidence of reflux esophagitis [18/102 (17.6%) vs 31/306 (10.1%), P = .043] and bile regurgitation [19/102 (18.6%) vs 30/306 (9.8%), P = .018] were higher in LT group. No correlation between the incidence of upper gastroduo...Continue Reading
References
Oct 7, 2006·Digestive Diseases and Sciences·Tomotaka AkatsuMasaki Kitajima
Apr 9, 2008·Gastroenterology·Annemarie C de VriesErnst J Kuipers
May 22, 2009·Gastroenterology·Timothy L Cover, Martin J Blaser
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Ignacio Herrero
Apr 12, 2012·Gut·Peter MalfertheinerUNKNOWN European Helicobacter Study Group
Jun 30, 2012·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Tetsunosuke ShimizuKazuhisa Uchiyama
Sep 13, 2012·Helicobacter·Takeshi Matsuhisa, Hafeza Aftab
Apr 20, 2013·World Journal of Gastroenterology : WJG·Teng-Fei ChenZhan-Ju Liu
Oct 10, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Harald SchremMoritz Kleine
Feb 3, 2016·Gastroenterology·Yi-Chia LeeDavid Y Graham
Feb 27, 2016·Transplantation Proceedings·D H JungS G Lee
Mar 21, 2016·Gastrointestinal Endoscopy·Satoki ShichijoKazuhiko Koike
Jun 24, 2016·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Chung-Sik GongSung-Gyu Lee
Mar 10, 2017·Cellular and Molecular Gastroenterology and Hepatology·Steven F Moss
Jan 31, 2018·Surgery Today·Takuro MiyazakiTakeshi Nagayasu
Jul 19, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Olivier SéréeJérôme Dumortier
Mar 1, 2019·Transplantation Proceedings·R HamuraK Yanaga
Nov 2, 2019·Journal of Gastroenterology·Susumu TakeHiroyuki Okada