Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning

Neurobiology of Learning and Memory
Anne PetzoldVolkmar Lessmann

Abstract

Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neural plasticity and, consequently, of memory formation. In hippocampus-dependent learning tasks BDNF also seems to play an essential role. However, there are conflicting results concerning the spatial learning ability of aging BDNF(+/-) mice in the Morris water maze paradigm. To evaluate the effect of chronic BDNF deficiency in the hippocampus on spatial learning throughout life, we conducted a comprehensive study to test differently aged BDNF(+/-) mice and their wild type littermates in the Morris water maze and to subsequently quantify their hippocampal BDNF protein levels as well as expression levels of TrkB receptors. We observed an age-dependent learning deficit in BDNF(+/-) animals, starting at seven months of age, despite stable hippocampal BDNF protein expression and continual decline of TrkB receptor expression throughout aging. Furthermore, we detected a positive correlation between hippocampal BDNF protein levels and learning performance during the probe trial in animals that showed a good learning performance during the long-term memory test.

References

Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Feb 10, 1997·Neuroreport·A Montkowski, F Holsboer
Mar 28, 1998·The European Journal of Neuroscience·S LinnarssonP Ernfors
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Mar 16, 2000·The EMBO Journal·S G KernieL F Parada
Mar 12, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christel GenoudEgbert Welker
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla
Jan 22, 2005·The Journal of Biological Chemistry·Jung Jin HwangJae-Young Koh
May 24, 2007·Journal of Neuroscience Research·Jung Jin HwangJae-Young Koh
Sep 25, 2009·Experimental Brain Research·Kurt GottmannVolkmar Lessmann
Dec 25, 2009·Current Molecular Pharmacology·Kiriana K CowansageMarie-H Monfils
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dennis C ChoiKerry J Ressler
Feb 16, 2010·Neuron·Michael S Fanselow, Hong-Wei Dong
Mar 12, 2010·Neuroscience·N C BerchtoldC W Cotman
Sep 15, 2010·Life Sciences·Sunita SharmaHolly Brown-Borg
Dec 9, 2010·Science Signaling·Patrick Mehlen
Jan 25, 2011·Genes, Brain, and Behavior·W ItoA Morozov
Mar 29, 2011·Neurobiology of Learning and Memory·Pauline ObiangVéronique Agin
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jody L SwiftJean-Martin Beaulieu
May 3, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kirk I EricksonKathryn A Roecklein
May 12, 2011·Neuropharmacology·Francesco PapaleoDaniel R Weinberger
Jul 1, 2011·BMC Neuroscience·Sung-Soo ParkStuart Maudsley
May 23, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Fang ZhangXinfu Zhou
Jul 21, 2012·Neuroscience and Biobehavioral Reviews·Joseph P KambeitzPhilip McGuire

❮ Previous
Next ❯

Citations

Nov 28, 2015·Neuromolecular Medicine·Mohammad Jodeiri FarshbafMohammad Hossein Nasr-Esfahani
Mar 8, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Danusa Mar ArcegoCarla Dalmaz
Oct 2, 2015·Aging and Disease·Josiane BudniAlexandra Ioppi Zugno
May 5, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nina GorléRoosmarijn E Vandenbroucke
Dec 15, 2015·Hippocampus·Janna AarseDenise Manahan-Vaughan
Apr 19, 2016·Expert Review of Neurotherapeutics·Carlos CamposSérgio Machado
Aug 16, 2016·Frontiers in Neuroendocrinology·Caterina PalleriaEmilio Russo
Feb 17, 2018·Cell and Tissue Research·Oliver von Bohlen Und Halbach, Viola von Bohlen Und Halbach
May 14, 2020·Brain Sciences·Claudio MolinariFrancesca Uberti
Jun 17, 2020·Cell and Tissue Research·Marta ZagrebelskyMartin Korte
Sep 16, 2017·Frontiers in Aging Neuroscience·Mona BuhusiCatalin V Buhusi
Feb 26, 2020·The Journal of Biological Chemistry·Marten SziborFrank N Gellerich
Apr 10, 2020·Frontiers in Cell and Developmental Biology·Theresa C Sutherland, Cédric G Geoffroy
Jun 14, 2019·Frontiers in Molecular Neuroscience·Vanessa CastelliMichele d'Angelo
Dec 2, 2020·International Journal of Molecular Sciences·Georgia-Ioanna KartalouVolkmar Lessmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.