Chronic Blockade of Brain Endothelin Receptor Type-A (ETA ) Reduces Blood Pressure and Prevents Catecholaminergic Overactivity in the Right Olfactory Bulb of DOCA-Salt Hypertensive Rats

International Journal of Molecular Sciences
Luis R CassinottiMarcelo S Vatta

Abstract

Overactivity of the sympathetic nervous system and central endothelins (ETs) are involved in the development of hypertension. Besides the well-known brain structures involved in the regulation of blood pressure like the hypothalamus or locus coeruleus, evidence suggests that the olfactory bulb (OB) also modulates cardiovascular function. In the present study, we evaluated the interaction between the endothelinergic and catecholaminergic systems in the OB of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Following brain ET receptor type A (ETA) blockade by BQ610 (selective antagonist), transcriptional, traductional, and post-traductional changes in tyrosine hydroxylase (TH) were assessed in the OB of normotensive and DOCA-salt hypertensive rats. Time course variations in systolic blood pressure and heart rate were also registered. Results showed that ETA blockade dose dependently reduced blood pressure in hypertensive rats, but it did not change heart rate. It also prevented the increase in TH activity and expression (mRNA and protein) in the right OB of hypertensive animals. However, ETA blockade did not affect hemodynamics or TH in normotensive animals. Present results support that brain ETA are not involved in blo...Continue Reading

References

Jun 15, 1977·European Journal of Pharmacology·A Nagaoka, W Lovenberg
May 1, 1992·The American Journal of Physiology·T Nakamura, Y Hayashida
Apr 1, 1989·Journal of the Autonomic Nervous System·B KamosinskaP Szulczyk
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·M D EslerG W Lambert
Jan 1, 1987·Journal of Psychiatric Research·H W Lahmeyer, S N Bellur
Feb 1, 1986·Experimental Neurology·O Heine, A M Galaburda
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·L A PohoreckyR J Wurtman
May 29, 1995·The Journal of Comparative Neurology·M C LangubJ P Herman
Sep 15, 1996·The American Journal of Cardiology·J C BarefootR B Williams
Jan 1, 1997·Pharmacology & Therapeutics·J P KellyB E Leonard
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Jan 7, 1998·The Journal of Comparative Neurology·K KurokawaJ Ochi
Aug 5, 1998·Brain Research·Z H ZhangS M Oppenheimer
Oct 9, 1998·Cardiovascular Research·Y M PintoD Ganten
Aug 24, 2000·The American Journal of Cardiology·W B Kannel
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angela J GrippoAlan Kim Johnson
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea S Di NunzioMarcelo S Vatta
Aug 27, 2002·Journal of Hypertension·Paul M Pilowsky, Ann K Goodchild
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Julia A MoffittAlan Kim Johnson
Jan 4, 2003·Hypertension·Marieke van OnnaPeter W de Leeuw
Feb 14, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven E WhitesallLouis G D'Alecy
Dec 1, 2004·Journal of Neurochemistry·Peter R DunkleyPhillip W Dickson
Dec 8, 2004·Current Protein & Peptide Science·Manuel RamírezFrancisco Alba
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·R A L DampneyL M McDowall
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Cai Song, Brian E Leonard
Jun 16, 2005·Vascular Pharmacology·Ernesto L Schiffrin
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Di-Song WangDing-Feng Su
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Markus P SchneiderDavid M Pollock
Aug 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sergei N Orlov, Alexander A Mongin
Dec 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guadalupe PerfumeMarcelo S Vatta
Apr 5, 2008·Clinical and Experimental Pharmacology & Physiology·Joanna M Abrams, John W Osborn

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
X-ray
PCR
electrophoresis

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.