Chronic Bronchitis Is Associated With Worse Symptoms and Quality of Life Than Chronic Airflow Obstruction

Chest
Paula M MeekYohannes Tesfaigzi

Abstract

COPD includes the chronic bronchitis (CB) and emphysema phenotypes. Although it is generally assumed that emphysema or chronic airflow obstruction (CAO) is associated with worse quality of life (QOL) than is CB, this assumption has not been tested. The current study's analyses from the Lovelace Smokers' Cohort (LSC) were validated in the COPD Gene Cohort (COPDGene). CB without CAO (CB only) was defined as self-reported cough productive of phlegm for ≥ 3 mo/y for 2 consecutive years and postbronchodilator FEV1/FVC ≥ 70%. CAO without CB (CAO only) was defined as a postbronchodilator FEV1/FVC < 70% with no evidence of CB. QOL outcomes were obtained from the St. George's Respiratory Questionnaire (SGRQ) and the 36-Item Short Form Health Survey (SF-36) questionnaires. A priori covariates included age, sex, pack-years of smoking, current smoking, and FEV1. Smokers with CB without CAO (LSC = 341; COPDGene = 523) were younger and had a greater BMI and less smoking exposure than did those with CAO only (LSC = 302; COPDGene = 2,208). Compared with the latter group, QOL scores were worse for those with CB only. Despite similar SGRQ Activity and SF-36 Role Physical and Physical Functioning, SGRQ Symptoms and Impact scores and SF-36 emotion...Continue Reading

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Citations

Jan 28, 2016·Current Opinion in Pulmonary Medicine·Gary L Jones
Apr 27, 2018·COPD·Rodrigo Vazquez GuillametYohannes Tesfaigzi
Feb 2, 2019·Annals of the American Thoracic Society·Victor Kim
Nov 24, 2017·The European Respiratory Journal·Filip MejzaUNKNOWN BOLD study collaborators
Jul 8, 2020·Radiology·Andrea S OhUNKNOWN Genetic Epidemiology of COPDGene Investigators
Sep 13, 2017·American Journal of Respiratory and Critical Care Medicine·André F S AmaralUNKNOWN BOLD Collaborative Research Group
Oct 30, 2020·Journal of Clinical Medicine·Joon Young Choi, Chin Kook Rhee

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