Chronic cadmium exposure attenuates the conditioned reinforcing properties of morphine and fentanyl

Brain Research
D K Miller, J R Nation

Abstract

Adult male rats were exposed ad libitum for 40 days to 100 ppm cadmium chloride through their diet, or an identical diet with no added cadmium. Conditioned place preference (CPP) was conducted in a 2-chamber apparatus in which all drugs were paired with the least-preferred side as determined on a pre-test. In Experiment 1. control and cadmium-exposed rats received 0, 0.6, 1.25, 2.5, or 5 mg/kg morphine sulfate (i.p.) for 4 days, and vehicle only for 4 days. Control animals showed a preference for the drug-paired side at 1.25, 2.5, and 5 mg/kg while the cadmium-exposed rats showed a preference at 5 mg/kg only. In Experiment 2, rats were implanted with cannulae into the lateral ventricles and 0, 2, 5 micrograms morphine sulfate was administered intracerebroventricularly (i.c.v.). An attenuation by cadmium again was observed, as control animals showed a place preference at 2 and 5 micrograms and cadmium-exposed animals showed preference at 5 micrograms only. In Experiment 3, increasing doses of the mu-opioid receptor agonist fentanyl (0, 0.0004, 0.004, and 0.04 mg/kg) were systemically administered (s.c.) and rats tested for CPP. While cadmium animals showed place preference only at 0.04 mg/kg, control animals showed preference at...Continue Reading

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Citations

Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·D K MillerG R Bratton
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Kelly R SmithGerald R Bratton
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Rodrigo VallesJack R Nation
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·D K MillerJ R Nation
Jan 8, 1999·Peptides·G A OlsonA J Kastin
Oct 18, 2003·Drug and Alcohol Dependence·Kelly R Smith, Jack R Nation
Nov 10, 2015·Toxicology·Archita Venugopal MenonJonghan Kim
Jan 30, 2007·Regulatory Peptides·Kristina W DavisP Shane Clifford
Aug 22, 2014·Journal of Pharmacological Sciences·Tomohisa MoriTsutomu Suzuki
Aug 10, 2017·The Journal of Pharmacology and Experimental Therapeutics·A J BrockC H Brennan
Nov 24, 2020·Psychopharmacology·Sean C Monroe, Anna K Radke
Mar 18, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrycja KupnickaIrena Baranowska-Bosiacka

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