Chronic caffeine exposure attenuates blast-induced memory deficit in mice

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
Ya-Lei NingYuan-Guo Zhou

Abstract

To investigate the effects of three different ways of chronic caffeine administration on blast- induced memory dysfunction and to explore the underlying mechanisms. Adult male C57BL/6 mice were used and randomly divided into five groups: control: without blast exposure, con-water: administrated with water continuously before and after blast-induced traumatic brain injury (bTBI), con-caffeine: administrated with caffeine continuously for 1 month before and after bTBI, pre-caffeine: chronically administrated with caffeine for 1 month before bTBI and withdrawal after bTBI, post-caffeine: chronically administrated with caffeine after bTBI. After being subjected to moderate intensity of blast injury, mice were recorded for learning and memory performance using Morris water maze (MWM) paradigms at 1, 4, and 8 weeks post-blast injury. Neurological deficit scoring, glutamate concentration, proinflammatory cytokines production, and neuropathological changes at 24 h, 1, 4, and 8 weeks post-bTBI were examined to evaluate the brain injury in early and prolonged stages. Adenosine A1 receptor expression was detected using qPCR. All of the three ways of chronic caffeine exposure ameliorated blast-induced memory deficit, which is correlated wi...Continue Reading

Citations

Sep 11, 2019·Pharmaceuticals·Daniel Pérez-PérezRoxana Magaña-Maldonado
Jun 9, 2020·Frontiers in Neurology·Peethambaran ArunJoseph B Long
Oct 6, 2020·Frontiers in Neurology·Aswati AravindBryan J Pfister
Jan 5, 2021·Frontiers in Neuroscience·Xiangpeng Ren, Jiang-Fan Chen
Oct 4, 2016·Behavioural Brain Research·Georgina Perez-GarciaGregory A Elder
Mar 17, 2018·Neuroscience and Biobehavioral Reviews·Laura B TuckerJoseph T McCabe

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