Chronic cerebral hypoperfusion: pathological and behavioral consequences

Neurosurgery
L H SekhonN C Weber

Abstract

Although the effects of acute ischemic insults to the brain are well known, the effects related to chronic ischemia are poorly delineated. The pathological and behavioral changes induced by a chronic noninfarctional reduction in cerebral blood flow of 25 to 50% maintained for 6 months were assessed. In each of 18 male Sprague-Dawley rats, an arteriovenous fistula was created in the neck via an anastomosis between the right external jugular vein and the right common carotid artery to induce cerebral hypoperfusion. Nineteen age-matched animals comprised a control group. Six months after surgery, the animals were examined using light and electron microscopic techniques, as well as via a battery of behavioral tests (motor, open field, and T-maze). Examination of the hippocampus by using light microscopy revealed disorganization of the CA1 sector with an increased number of astrocytes. Transmission electron microscopy of the CA1 region demonstrated neurons with increased lipofuscin pigment and central nucleoli and astrocytes with more numerous cytosolic mitochondria. Motor performance testing revealed no gross motor deficits, although open-field assessment demonstrated increased exploratory behavior in rats with fistulas. Finally, T...Continue Reading

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Citations

Nov 6, 2002·Journal of the Neurological Sciences·Cristina SartiDomenico Inzitari
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Jul 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·L H SekhonN C Weber
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Sep 17, 2002·Neurosurgery·Lali H S Sekhon, Michael K Morgan
Feb 13, 2018·Experimental and Therapeutic Medicine·Xiaoqin HuChengyan Li

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