PMID: 11911982Mar 26, 2002Paper

Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat

Neuroscience Letters
David D FullerGordon S Mitchell

Abstract

We hypothesized that pretreatment with chronic cervical dorsal rhizotomy (CDR; C(3)-C(6)) would reveal ineffective crossed spinal pathways to phrenic motoneurons. Anesthetized CDR (1 week post-rhizotomy) and control rats were spinally hemisected at C(2), and phrenic potentials were evoked by stimulating the ventrolateral funiculus contralateral and rostral to hemisection. Phrenic potentials contralateral to the stimulating electrode were evoked at lower stimulus currents (CDR=640 +/- 46 microA; control=900 +/- 50 microA; P<0.05) and potential amplitude was significantly greater in CDR versus control rats (P<0.05). The serotonin receptor antagonist methysergide (4 mg/kg, i.v.) had no effect on the crossed phrenic potential amplitude (91+/-17% of control at 800 microA; P>0.05). Thus, CDR enhances crossed phrenic pathways but serotonin receptor activation is not necessary to maintain this effect.

References

Dec 1, 1979·Experimental Neurology·H G Goshgarian
Feb 22, 1991·The Journal of Comparative Neurology·S D WangM Murray
Nov 30, 1999·Nature·B Berninger, M Poo
Aug 30, 2000·Respiration Physiology·D D FullerG S Mitchell
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Citations

Jul 19, 2005·Experimental Neurology·M Beth Zimmer, Harry G Goshgarian
Dec 18, 2013·Respiratory Physiology & Neurobiology·L C GillD D Fuller
Aug 25, 2009·Respiratory Physiology & Neurobiology·Michael A LanePaul J Reier
Aug 26, 2009·Respiratory Physiology & Neurobiology·Gary C Sieck, Carlos B Mantilla
Sep 9, 2008·Trends in Neurosciences·Michael A LanePaul J Reier
Jul 3, 2007·Experimental Neurology·M Beth ZimmerHarry G Goshgarian
Oct 19, 2006·Experimental Neurology·M Beth Zimmer, Harry G Goshgarian
Jun 10, 2015·Experimental Neurology·Michael George Zaki Ghali, Vitaliy Marchenko
Feb 27, 2015·Frontiers in Neural Circuits·Daryl P Fields, Gordon S Mitchell
May 22, 2016·Experimental Neurology·David D Fuller, Gordon S Mitchell
Mar 15, 2006·Respiratory Physiology & Neurobiology·Gordon S Mitchell, Tony G Babb
Jul 6, 2007·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Nov 5, 2005·Journal of Applied Physiology·David D FullerGordon S Mitchell
Feb 7, 2003·Journal of Applied Physiology·Carlos B Mantilla, Gary C Sieck
Aug 2, 2017·Neural Regeneration Research·Michael George Zaki Ghali
Jan 18, 2003·Journal of Applied Physiology·H V Forster
Dec 18, 2002·Journal of Applied Physiology·Gordon S Mitchell, Stephen M Johnson
Aug 25, 2017·Journal of Neurophysiology·Jayakrishnan NairDavid D Fuller

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