Chronic Chagas disease: presence of parasite DNA in the oesophagus of patients without megaoesophagus

Transactions of the Royal Society of Tropical Medicine and Hygiene
Annamaria Ravara VagoDébora d'Avila Reis

Abstract

We have previously amplified Trypanosoma cruzi DNA by polymerase chain reaction (PCR) from the oesophagus of chagasic patients with megaoesophagus, whilst immunohistochemical analysis failed to detect T. cruzi antigen in the oesophagus of chagasic patients without megaoesophagus. During 2000-01, we tested for the presence of T. cruzi DNA in oesophageal tissue from 9 chronic chagasic patients without megaoesophagus and 5 were positive by PCR, which suggests that other factors, besides simply the presence of the parasite, should be considered in the understanding of the pathogenesis of megaoesophagus.

References

Mar 1, 1993·The American Journal of Tropical Medicine and Hygiene·E M JonesT L McCurley
May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·D d'Avila ReisC R Machado

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Citations

Jul 8, 2011·Clinical Microbiology Reviews·Antonio R L TeixeiraNadjar Nitz
Dec 7, 2006·Postgraduate Medical Journal·A R L TeixeiraC A Santos-Buch
Aug 17, 2012·Virchows Archiv : an International Journal of Pathology·Sheila Jorge AdadAlessandro Adad Jammal
Nov 26, 2013·Memórias do Instituto Oswaldo Cruz·Nívia Carolina Nogueira-PaivaCláudia Martins Carneiro
Feb 23, 2011·Memórias do Instituto Oswaldo Cruz·Gláucia E Barbosa MarconSandra C Botelho Costa

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