Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics

Psychiatry Research
Stefan GazdzinskiDieter J Meyerhoff

Abstract

Memory function is largely mediated by the medial temporal lobe (MTL), and its compromise has been observed in alcohol dependence and chronic cigarette smoking. The effects of heavy alcohol consumption and chronic smoking on hippocampal volumes and MTL metabolites and their recovery during abstinence from alcohol have not been assessed. Male alcoholics in treatment (ALC) [13 smokers (sALC) and 11 non-smokers (nsALC)] underwent quantitative magnetic resonance imaging and short-echo proton magnetic resonance spectroscopic imaging at 1 week and 1 month of sobriety. Outcome measures were compared with 14 age-matched, non-smoking light-drinkers and were related to visuospatial learning and memory. Over 1 month of abstinence, N-acetyl-aspartate, a neuronal marker, and membrane-associated choline-containing metabolites normalized in the MTL of nsALC subjects, but remained low in the MTL of sALC subjects. Metabolite concentration changes in both groups were associated with improvements in visuospatial memory. Hippocampal volumes increased in both groups during abstinence, but increasing volumes correlated with visuospatial memory improvements only in nsALC subjects. In summary, chronic cigarette smoking in alcohol-dependent men appears...Continue Reading

References

Jan 16, 1989·Brain Research·D DurandP L Carlen
Nov 1, 1982·Journal of Studies on Alcohol·H A Skinner, W J Sheu
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·P R MartinM R Willcott
Aug 1, 1995·Acta Psychiatrica Scandinavica·W TrabertG Huber
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·E V SullivanA Pfefferbaum
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·R D HurtB K Bruce
Oct 1, 1995·Alcoholism, Clinical and Experimental Research·A PfefferbaumK O Lim
Nov 1, 1995·Behavioural Brain Research·L E Jarrard
Jan 1, 1997·Journal of Addictive Diseases·C S PomerleauO F Pomerleau
Sep 2, 1998·Psychopharmacology·E D Levin, B B Simon
Dec 24, 1998·Cerebral Cortex·A J HardingJ J Kril
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·D SeitzW Grodd
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·L Korbo
Apr 10, 1999·Archives of General Psychiatry·I AgartzD W Hommer
Apr 14, 2000·Behavioural Brain Research·M P LaaksoJ Tiihonen
Jun 1, 2000·Alcoholism, Clinical and Experimental Research·E V SullivanA Pfefferbaum
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·M A PrendergastJ M Littleton
Apr 27, 2001·The Anatomical Record·B Ross, S Bluml
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N SchuffM W Weiner
Jun 22, 2001·Drug and Alcohol Dependence·S E Gilman, H D Abraham
Sep 3, 2002·Journal of Magnetic Resonance Imaging : JMRI·Yuan-Yu HsuMichael W Weiner
Jan 30, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S BleichJ Kornhuber
May 30, 2003·American Journal of Public Health·Marcus RichardsMichael E J Wadsworth
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·I J DearyL J Whalley
Aug 7, 2003·Journal of the International Neuropsychological Society : JINS·John A SchinkaAmy Borenstein Graves
Sep 6, 2003·Age and Ageing·Robert D HillLars Bäckman
Dec 16, 2003·Psychological Medicine·D M FergussonL J Horwood
Dec 19, 2003·Free Radical Biology & Medicine·Siobhan E MoriartyPaul Sternberg
Jan 7, 2004·Biological Psychiatry·Arthur L BrodyEdythe D London
Mar 3, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Debra J Romberger, Kathleen Grant
Mar 17, 2004·Current Opinion in Pharmacology·Paul A NewhouseAbhay Singh
Apr 15, 2004·Current Opinion in Neurobiology·Gerd KempermannFred H Gage
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·D J MeyerhoffM W Weiner
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kimberly Nixon, Fulton T Crews
Oct 30, 2004·The American Journal of Psychiatry·Poul Videbech, Barbara Ravnkilde
Dec 1, 2004·The American Journal of Psychiatry·Hermann Winter, Eva Irle
Dec 8, 2004·Journal of Psychopharmacology·Kristi A SaccoTony P George
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Timothy C DurazzoDieter J Meyerhoff
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Natalie A CeballosSara Jo Nixon
Mar 1, 2005·Pharmacological Reviews·Janne HukkanenNeal L Benowitz

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Citations

Oct 7, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Timothy C DurazzoDieter J Meyerhoff
Feb 19, 2014·Psychopharmacology·Joseph O'NeillEdythe D London
Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vibhuti SrivastavaDavid Goldman
Feb 6, 2010·Brain : a Journal of Neurology·Stefan GazdzinskiDieter J Meyerhoff
Aug 23, 2011·Addictive Behaviors·Jeff BoissoneaultSara Jo Nixon
Sep 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·E F Domino
Aug 4, 2009·Alcoholism, Clinical and Experimental Research·George FeinJerome Barakos
Jun 11, 2008·Alcoholism, Clinical and Experimental Research·Dieter J Meyerhoff, Timothy C Durazzo
Oct 18, 2012·Alcoholism, Clinical and Experimental Research·Julia van EijkGabriele Ende
May 21, 2013·Alcoholism, Clinical and Experimental Research·Timothy C DurazzoDieter J Meyerhoff
Jan 29, 2011·Annals of the New York Academy of Sciences·K M Kantak, B Á Nic Dhonnchadha
Apr 12, 2014·Alcoholism, Clinical and Experimental Research·Thomas P SchmidtDieter J Meyerhoff
Jul 21, 2012·Human Brain Mapping·Amy KuceyeskiAshish Raj
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Timothy C DurazzoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 25, 2016·Neuroscience and Biobehavioral Reviews·Xun YangQiyong Gong
Nov 10, 2016·Psychiatry Research. Neuroimaging·Jeonghwan LeeSiekyeong Kim
Oct 18, 2016·Genes, Brain, and Behavior·N W Gilpin, J L Weiner
Apr 5, 2017·Psychological Medicine·S WilsonW G Iacono
Feb 5, 2015·Ciência & saúde coletiva·Ivana Oliveira Preto BaccariSabrina Stefanello
Apr 20, 2018·Alcoholism, Clinical and Experimental Research·Xiaowei ZouDieter J Meyerhoff
Mar 14, 2012·Nature Reviews. Neurology·Majid FotuhiClifford Jack
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie C Licata, Perry F Renshaw
Nov 23, 2010·Alcoholism, Clinical and Experimental Research·Stefan GazdzinskiDieter J Meyerhoff
Jul 23, 2011·Alcoholism, Clinical and Experimental Research·Mira Bühler, Karl Mann
Mar 30, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Moussa A Chalah, Samar S Ayache
May 11, 2018·Addiction·Katrin CharletAnne Beck
May 1, 2021·Brain Sciences·Natalie N NawarawongKimberly Nixon
Jul 18, 2019·Molecular Neuropsychiatry·Eric A WoodcockKelly P Cosgrove

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