Abstract
Chronic administration of pharmacological levels of beta2-agonists have been shown to have toxic effects on the heart; however, no data exist on cardiac function after chronic clenbuterol administration. The purpose of this study was to examine the effect of therapeutic levels of clenbuterol on cardiac performance. Twenty unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 microg.kg(-1) twice daily 5 d.wk(-1)) plus exercise (20 min at 50% .VO(2max)) (CLENEX; N = 6), clenbuterol (CLEN; N = 6), exercise (EX; N = 4), and control (CON; N = 4). M-mode and two-dimensional echocardiography (2.5-MHz sector scanner transducer) were used to measure cardiac size and function before and immediately after an incremental exercise test, before and after 8 wk of drug and/or exercise treatments. After treatment, CLENEX and CLEN demonstrated significantly higher left ventricular internal dimension (LVD) at end diastole (+23.7 +/- 4.8%; +25.6 +/- 4.1%), LVD at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), interventricular septal wall thickness (IVS) at end diastole (+28.9 +/- 11.0%; +30.7 +/- 7.0%), IVS at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), and left ventricular posterior wall systolic thickness (+43.1 ...Continue Reading
References
Sep 1, 1992·Australian Veterinary Journal·R F SlocombeW M Bayly
Sep 1, 1989·Journal of Animal Science·M C ClaeysJ L Sartin
Mar 1, 1981·Journal of Veterinary Pharmacology and Therapeutics·J E ShaplandD G Hatfield
Jan 1, 1994·Archives of Toxicology·S E Libretto
Aug 1, 1993·Circulation·J E AdamsA S Jaffe
Jul 1, 1994·Equine Veterinary Journal·D F ErichsenT J Kennedy
Mar 1, 1996·Journal of Applied Physiology·C P IngallsS B Smith
Dec 16, 1997·Cardiology·A J SiegelK B Lewandrowski
Dec 24, 1997·Acta Physiologica Scandinavica·J SuzukiT Koyama
Apr 16, 1998·Cardiovascular Research·K WongM H Yacoub
May 15, 1998·The Journal of Pharmacy and Pharmacology·J C CubríaD Ordóñez
Jun 5, 1998·The American Journal of Physiology·A J BakkerD G Stephenson
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·G S LynchJ A Faulkner
Jul 8, 1999·The Journal of the American Board of Family Practice·M S Rice, D C MacDonald
Jan 21, 2000·Journal of Applied Physiology·M FlückF W Booth
Feb 25, 2000·Journal of the American Veterinary Medical Association·B B MartinA D Sage
May 10, 2000·Circulation·N W GuldnerH H Sievers
Jul 8, 2000·Circulation Research·A R Marks
Jul 26, 2000·Journal of the American Veterinary Medical Association·C J CornelisseF J Derksen
Citations
Dec 30, 2011·American Journal of Veterinary Research·Jennifer R ReadRose D Nolen-Walston
Dec 14, 2004·Journal of Applied Physiology·Jatin G BurnistonDavid F Goldspink
Dec 17, 2014·Nutrition and Cancer·Patrizia MondelloVincenzo Pitini
Mar 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juliane C CamposJulio C B Ferreira
May 25, 2012·American Journal of Veterinary Research·Jessica A ThompsonRebecca S McConnico
Apr 25, 2015·American Journal of Veterinary Research·Rose D Nolen-WalstonLawrence R Soma
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Paul GregorevicGordon S Lynch
Jun 19, 2013·Equine Veterinary Journal·H K KnychD S McKemie
Jan 30, 2007·Pharmacology & Therapeutics·Gordon S LynchJames G Ryall