PMID: 11932573Apr 5, 2002Paper

Chronic clenbuterol administration negatively alters cardiac function

Medicine and Science in Sports and Exercise
Margaret M SleeperK H McKeever

Abstract

Chronic administration of pharmacological levels of beta2-agonists have been shown to have toxic effects on the heart; however, no data exist on cardiac function after chronic clenbuterol administration. The purpose of this study was to examine the effect of therapeutic levels of clenbuterol on cardiac performance. Twenty unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 microg.kg(-1) twice daily 5 d.wk(-1)) plus exercise (20 min at 50% .VO(2max)) (CLENEX; N = 6), clenbuterol (CLEN; N = 6), exercise (EX; N = 4), and control (CON; N = 4). M-mode and two-dimensional echocardiography (2.5-MHz sector scanner transducer) were used to measure cardiac size and function before and immediately after an incremental exercise test, before and after 8 wk of drug and/or exercise treatments. After treatment, CLENEX and CLEN demonstrated significantly higher left ventricular internal dimension (LVD) at end diastole (+23.7 +/- 4.8%; +25.6 +/- 4.1%), LVD at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), interventricular septal wall thickness (IVS) at end diastole (+28.9 +/- 11.0%; +30.7 +/- 7.0%), IVS at end systole (+29.2 +/- 8.7%; +40.1 +/- 7.9%), and left ventricular posterior wall systolic thickness (+43.1 ...Continue Reading

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Citations

Dec 30, 2011·American Journal of Veterinary Research·Jennifer R ReadRose D Nolen-Walston
Dec 14, 2004·Journal of Applied Physiology·Jatin G BurnistonDavid F Goldspink
Dec 17, 2014·Nutrition and Cancer·Patrizia MondelloVincenzo Pitini
Mar 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juliane C CamposJulio C B Ferreira
Apr 25, 2015·American Journal of Veterinary Research·Rose D Nolen-WalstonLawrence R Soma
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Paul GregorevicGordon S Lynch
Jan 30, 2007·Pharmacology & Therapeutics·Gordon S LynchJames G Ryall

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