Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation

Behavioural Pharmacology
Man LiFeng Shao

Abstract

Isolation rearing produces significant behavioral and neurochemical dysfunctions in rodents, which resemble the symptoms of schizophrenia. Clozapine, one of the atypical antipsychotics, is widely used in the treatment of schizophrenia patients and in experimental studies. In this study, male Sprague Dawley rats were randomly assigned to either group-reared or isolation-reared conditions during postnatal days (PNDs) 21-34. During PNDs 46-55, the rats were subjected to chronic clozapine (1.0 mg/kg for 10 days) or saline treatment. On PND 56, all rats underwent behavioral testing and then were sacrificed for biochemical testing. The results indicated that adolescent social isolation induced impairments in prepulse inhibition and reversal learning, and clozapine injection improved the prepulse inhibition disruption but not reversal learning ability. Furthermore, clozapine administration reversed the increased brain-derived neurotrophic factor (BDNF) mRNA level in the medial prefrontal cortex (mPFC) that was induced by adolescent isolation. However, clozapine decreased the BDNF mRNA level in the mPFC in group-reared rats. Together, our findings provide additional evidence that a low dose of chronic clozapine treatment could improve ...Continue Reading

References

Oct 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A L HoffJ G Csernansky
Apr 29, 1998·Journal of Clinical Psychopharmacology·T Sharma, D Mockler
Apr 2, 1999·Trends in Pharmacological Sciences·C A Altar
Oct 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nii Addy, Edward D Levin
Feb 3, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nii A AddyEdward D Levin
Apr 12, 2005·Pharmacology, Biochemistry, and Behavior·Vera BubeníkováColleen Dockery
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary C BaquetKevin R Jones
Dec 17, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edward D Levin, N Channelle Christopher
Jan 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agnès L AuclairAdrian Newman-Tancredi
Feb 17, 2006·European Journal of Pharmacology·Kimmo Ingman, Esa R Korpi
Mar 21, 2006·Journal of Psychiatric Research·Rodrigo W GrilloDiogo R Lara
Nov 11, 2006·Psychological Medicine·Craig MorganPaul Fearon
Mar 16, 2007·Pharmacology, Biochemistry, and Behavior·Edward D LevinCharles Perraut
Jul 1, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiaohong ZhaoShuchang He
Nov 28, 2009·The International Journal of Neuropsychopharmacology·Anilkumar PillaiSahebarao P Mahadik
Jun 23, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Raquel LevinVanessa Costhek Abílio
Jan 28, 2012·Pharmacology & Therapeutics·Sivasankaran Balaratnasingam, Aleksandar Janca
Feb 28, 2013·Current Psychiatry Reports·Anda GershonRuth O'Hara

❮ Previous
Next ❯

Citations

Oct 6, 2020·Frontiers in Integrative Neuroscience·Hao ZhouWeiwen Wang
Aug 17, 2021·Journal of Dual Diagnosis·Iván EcheverriaGonzalo Haro
Aug 26, 2021·Neuroscience Letters·Eliyahu DremencovSaak V Ovsepian
Oct 7, 2021·International Journal of Clinical Practice·Zahra Taheri ZadehKhadijeh Esmaeilpour

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
PCR

Software Mentioned

Ethovision
SPSS

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here