Chronic cocaine effects on peripheral biogenic amines: a long-term reduction in peripheral dopamine and phenylethylamine production

European Journal of Pharmacology
F KaroumR J Wyatt

Abstract

The short- (during 12 h after last treatment) and long- (6 weeks after last treatment) term effects of repeated administration of cocaine on the total output of norepinephrine (NE) and its metabolites (sum NE), dopamine (DA) and its metabolites (sum DA) as well as the excretion of 5-hydroxyindoleacetic acid (5-HIAA) and phenylethylamine were evaluated in rats. The concentration of NE, DA and 3,4-dihydroxyphenylacetic acid (DOPAC) in the celiac ganglion after 1, 2 and 3 weeks of repeated cocaine administration were also measured. Sum NE remained unchanged during the cocaine treatment but NE and normetanephrine excretions were significantly decreased and increased respectively. 5-HIAA excretion was significantly reduced only after 3 weeks cocaine treatment. In the celiac ganglion NE and DOPAC contents showed tendencies towards being increased and decreased respectively. DA content was not changed. The excretions of DA, DOPAC, homovanillic acid (HVA) and phenylethylamine were significantly reduced during chronic exposure to cocaine. The above short-term changes in DA and phenylethylamine persisted for periods as long as 6 weeks after 1 week repeated exposure to cocaine. It is concluded that chronic exposure to cocaine can produce ...Continue Reading

References

Aug 1, 1978·Journal of Comparative and Physiological Psychology·G FouriezosR A Wise
Sep 1, 1979·Drug and Alcohol Dependence·G C WagnerC R Schuster
Feb 1, 1976·Drug and Alcohol Dependence·L S SeidenC R Schuster
Mar 1, 1986·Lancet·J F JekelP Cartwright
Oct 1, 1986·Brain Research Bulletin·A J GreenshawT V Nguyen
Dec 4, 1986·The New England Journal of Medicine·L L Cregler, H Mark
May 1, 1985·Pharmacology, Biochemistry, and Behavior·L C GuanJ B Becker
Apr 4, 1980·European Journal of Pharmacology·S G SpecialeR J Wyatt
Apr 10, 1980·Nature·T HökfeltM Schultzberg
Nov 11, 1983·European Journal of Pharmacology·C PimouleS Z Langer
Jan 1, 1980·Psychopharmacology·M E Risner, B E Jones
Nov 30, 1981·Brain Research·F KaroumR J Wyatt

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