Chronic cold exposure stimulates microvascular remodeling preferentially in oxidative muscles in rats

The Japanese Journal of Physiology
J SuzukiT Koyama

Abstract

The effects of 4-week cold exposure on capillary geometry, particularly in terms of the distribution of arteriolar and venular capillaries and their capillary domain areas, were studied for different types of skeletal muscles in male Wistar rats. Morphological data for capillaries and muscles were obtained from muscle cross-sections exposed to a double-staining method that distinguishes arteriolar portions from venular portions of capillaries. In soleus (SOL; type I fibers) and the deep portion of gastrocnemius (GASd; type I and IIa fibers) muscles, total capillary density and density of arteriolar capillary were significantly greater in cold-acclimated (CA) rats than in warm control (WC) rats (p < 0.05). In the superficial portion of the gastrocnemius (GASs; type IIb fibers), however, these changes in capillarity were not observed. After cold acclimation, fiber cross-sectional area was significantly decreased by 21, 28 and 15% in SOL, GASd and GASs (p < 0.05), respectively. In SOL and GASd but not in GASs, capillary domain areas of arteriolar, intermediate and venular portions in CA were significantly smaller than those of the respective portions in WC (p < 0.05). Succinate dehydrogenase activity was significantly increased af...Continue Reading

Citations

Jul 13, 2000·Free Radical Biology & Medicine·C SelmanJ R Speakman
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Jun 6, 2002·The Japanese Journal of Physiology·Takeshi NomuraYoshinobu Ohira
Nov 12, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Wataru MizunoyaYoshihide Ikeuchi
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Apr 2, 2021·European Journal of Applied Physiology·Antonis EliaMatthew J Lees
Jun 18, 2021·Frontiers in Physiology·Garoa SantocildesJoan Ramon Torrella
Aug 3, 2021·Frontiers in Sports and Active Living·Mohammed IhsanRobert Allan

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