Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus

Metabolic Brain Disease
Aleksey PiskunovNatalia Gulyaeva

Abstract

Hippocampus is believed to be selectively vulnerable to stress. We hypothesized that this phenomenon may be mediated by relatively high vulnerability to neuroinflammation related to impairments of local glucocorticoid metabolism and signaling. We have evaluated inflammatory responses induced by acute or chronic combined stress in the cerebral cortex and hippocampus as well as circulating and brain corticosterone (CS) levels as well as expression of corticosterone target genes. The hippocampus showed higher stress-induced expression of the proinflammatory cytokine IL-1β as compared to the cerebral cortex. A month after the termination of the chronic stress, IL-1β mRNA in the cerebral cortex reached control level, while in the hippocampus it remained significantly increased. Under chronic stress, the maladaptive inflammatory response in hippocampus was accompanied by a significant increase in local CS levels, as compared to cerebral cortex. Under acute stress, the increased CS level induced changes in CS-regulated genes expression (CRF and IGF1), while this phenomenon was not observed after chronic stress. Thus, the hippocampus appears to be more vulnerable to stress-induced inflammation as compared to the neocortex and demonstra...Continue Reading

References

Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W J Streit
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S W LeeA C Allison
Apr 1, 1995·Current Opinion in Neurobiology·B S McEwen, R M Sapolsky
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
May 1, 1997·Molecular Psychiatry·B S McEwen
Jul 19, 2000·Journal of Neurochemistry·L F García-FernándezA Muñoz
Feb 4, 2003·Journal of Neurochemistry·Klaus DinkelRobert M Sapolsky
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R M de PablosA Machado
Jul 18, 2006·Neurobiology of Disease·Sabine ChourbajiPeter Gass
Dec 30, 2006·Brain, Behavior, and Immunity·Shawn F Sorrells, Robert M Sapolsky
Jul 24, 2007·The Journal of Biological Chemistry·Michael A KlieberYves A Muller
Jan 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C D MunhozJ C Leza
May 7, 2009·Brain, Behavior, and Immunity·Jesse C StewartThomas W Kamarck
Nov 13, 2009·Annals of the New York Academy of Sciences·Andrea H MarquesEsther M Sternberg
Dec 10, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A O TishkinaN V Gulyaeva
Apr 29, 2010·Current Psychiatry Reports·Raymond L Ownby
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta KuberaMichael Maes
Oct 12, 2010·Brain, Behavior, and Immunity·Thaddeus W W Pace, Christine M Heim
Jun 26, 2012·Steroids·Nan YangLaura C Matthews
Jan 9, 2014·Pharmacological Reports : PR·Anna Gądek-MichalskaJan Bugajski
Oct 16, 2014·Brain, Behavior, and Immunity·Seung Ho JungJohn F Sheridan

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Citations

May 21, 2019·Brain, Behavior, and Immunity·Albert E TowersGregory G Freund
Apr 10, 2021·Biochemistry. Biokhimii︠a︡·Alexey P BolshakovNatalia V Gulyaeva

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