Chronic Comorbidities Among Survivors of Adolescent and Young Adult Cancer.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Chun R ChaoSaro H Armenian

Abstract

To describe the incidence, relative risk, and risk factors for chronic comorbidities in survivors of adolescent and young adult (AYA) cancer. This retrospective cohort study included 2-year survivors of AYA cancer diagnosed between age 15 and 39 years at Kaiser Permanente Southern California from 2000 to 2012. A comparison cohort without cancer was individually matched (13:1) to survivors of cancer on age, sex, and calendar year. Using electronic medical records, all participants were followed through December 31, 2014, for chronic comorbidity diagnoses. Poisson regression was used to evaluate the association between cancer survivor status and risk of developing each comorbidity. The associations between cumulative exposure to chemotherapy and radiation therapy and selected comorbidities were examined for survivors of cancer. The cohort included 6,778 survivors of AYA cancer and 87,737 persons without a history of cancer. The incidence rate ratio (IRR) for survivors of cancer was significantly increased for nearly all comorbidities examined. IRR ranged from 1.3 (95% CI, 1.2 to 1.4) for dyslipidemia to 8.3 (95% CI, 4.6 to 14.9) for avascular necrosis. Survivors of AYA cancer had a 2- to 3-fold increased risk for cardiomyopathy, ...Continue Reading

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Citations

Feb 11, 2021·Pediatric Blood & Cancer·Courtney E WimberlyKyle M Walsh
Dec 29, 2020·World Journal of Gastrointestinal Oncology·Jie RenYong Wan
Jun 14, 2021·International Journal of Radiation Oncology, Biology, Physics·Darren ZuroSusanta K Hui
Sep 3, 2021·Journal of Cancer Survivorship : Research and Practice·Alexandra SmithLarissa Nekhlyudov
Nov 18, 2021·Pediatric Blood & Cancer·Courtney E WimberlyKyle M Walsh

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