PMID: 9006658Jan 1, 1997Paper

Chronic constriction model of rat sciatic nerve: nerve blood flow, morphologic and biochemical alterations

Acta Neuropathologica
H SasakiP A Low

Abstract

We evaluated the nerve blood flow (NBF), light and electron microscopy, and adrenergic innervation of rat sciatic nerve at 2-45 days after the application of four loose ligatures. Ischemia developed at the lesion edge, creating an endoneurial dam. Calcitonin gene-related peptide, norepinephrine and NBF were increased within the lesion. Morphologic alterations consisted of early endoneurial edema, followed by myelinated fiber degeneration, with relative sparing of small myelinated and unmyelinated nerve fibers, and leukocyte adhesion to microvessels. Axonal degeneration predominated over demyelination. At 45 days, profuse regeneration of small myelinated fibers was seen. The mechanism of lesional sensitization is discussed.

Citations

Feb 11, 2004·Experimental Neurology·Haruyasu IidaPhillip A Low
Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·L L TeunissenN C Notermans
Jan 22, 2020·Respiratory Research·K KahnertR A Jörres
Sep 5, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bimlesh KumarIndu Melkani
Jan 13, 2021·Journal of the Peripheral Nervous System : JPNS·Preet G S MakkerGila Moalem-Taylor

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