Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial

European Journal of Nutrition
Boon ChewJeffrey Blumberg

Abstract

We studied the health benefits of low calorie cranberry beverage consumption on glucoregulation, oxidative damage, inflammation, and lipid metabolism in overweight but otherwise healthy humans. 78 overweight or obese men and women (30-70 years; BMI 27-35 kg/m2) with abdominal adiposity (waist: hip > 0.8 for women and > 0.9 for men; waist: height ≥ 0.5) consumed 450 mL placebo or low calorie, high polyphenol cranberry extract beverage (CEB) daily for 8 week in a randomized, double-blind, placebo-controlled, parallel design trial. Blood and urine samples were collected after overnight fast at baseline and after 8 weeks of daily beverage consumption. Blood and urine samples were also collected during 3 oral glucose tolerance test (OGTT) challenges: (1) pre-intervention without the test beverages, (2) following a single dose of placebo or CEB at baseline (week 0), and (3) following a single dose of placebo or CEB at 8 week. Compared to placebo, a single CEB dose at baseline lowered endothelin-1 and elevated nitric oxide and the reduced:oxidized glutathione ratio (P < 0.05). Interferon-γ was elevated (P < 0.05) after a single CEB dose at baseline; however, after 8 week of CEB intervention, fasting C-reactive protein was lower (P < 0...Continue Reading

References

Mar 1, 1996·Immunology Today·T R Mosmann, S Sad
Feb 16, 2002·Journal of the American Dietetic Association·Frances E ThompsonRegina G Ziegler
Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T M Wallace, D R Matthews
Jan 29, 2003·Circulation·Edward T H Yeh, James T Willerson
Aug 28, 2003·Diabetes Care·Belinda K Chambers, Mary Ellen Camire
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Jan 22, 2004·Journal of Agricultural and Food Chemistry·Kai Zhang, Yuegang Zuo
Jan 11, 2005·The American Journal of Clinical Nutrition·Jan Ø MoskaugRune Blomhoff
May 24, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elizabeth A MilesPhilip C Calder
Jul 25, 2006·Bioscience, Biotechnology, and Biochemistry·Ryoko OhnishiTakashi Yoshida
Aug 23, 2006·The British Journal of Nutrition·Guillaume RuelCharles Couillard
Apr 27, 2007·Investigative Ophthalmology & Visual Science·Paul E MilburyJeffrey B Blumberg
Dec 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·I T LeeW H-H Sheu
Jan 30, 2010·Journal of Agricultural and Food Chemistry·Paul W CatonRoger Corder
Apr 9, 2010·The Journal of Nutrition·Paul E MilburyJeffrey B Blumberg
Mar 18, 2011·The American Journal of Clinical Nutrition·Mustali M DohadwalaJoseph A Vita
Feb 2, 2012·Anti-cancer Agents in Medicinal Chemistry·Francois GhiringhelliDominique Delmas
Aug 22, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y ZhuY Yang
Aug 22, 2012·The British Journal of Nutrition·Laura HanskeAnnett Braune
Jan 29, 2013·Nutrition Research·Guillaume RuelCharles Couillard
Apr 23, 2013·The American Journal of Clinical Nutrition·Charles CzankColin D Kay
Oct 5, 2013·Current Atherosclerosis Reports·J Y TohMary F F Chong
Aug 5, 2014·European Journal of Nutrition·Anette HjartåkerElisabete Weiderpass
Sep 26, 2014·Current Atherosclerosis Reports·Lona J Kroese, Peter G Scheffer
Apr 3, 2015·The American Journal of Clinical Nutrition·Kerry L IveyRichard L Prince

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Citations

May 30, 2019·Food & Function·Livia de Almeida AlvarengaDenise Mafra
Sep 25, 2020·Genes & Nutrition·M UlaszewskaC Manach
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christina M Coleman, Daneel Ferreira
Aug 19, 2020·Molecular Biology Reports·Ayane MikamiTakeshi Shimosato
Apr 4, 2021·Nutrients·Monika KurpikJadwiga Jodynis-Liebert
Jan 6, 2022·The Cochrane Database of Systematic Reviews·Sara BergwallStefan Acosta

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Methods Mentioned

BETA
urine sample collection
ELISA
urine collected

Clinical Trials Mentioned

NCT01527617

Software Mentioned

SAS
Quansys Q - View

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