Chronic consumption of a low-fat diet improves cardiometabolic risk factors according to the CLOCK gene in patients with coronary heart disease

Molecular Nutrition & Food Research
Francisco Gomez-DelgadoPablo Perez-Martinez

Abstract

Single nucleotide polymorphisms (SNPs) of the circadian locomotor output cycles kaput (CLOCK) gene have been associated with cardiometabolic conditions such as obesity and dyslipidemia. Our aim was to examine whether the chronic consumption of two healthy diets interacts with SNPs of the CLOCK gene in order to improve lipid metabolism and inflammation status in patients with coronary heart disease (CHD). The diets were low-fat (LF) diet and Mediterranean diet (MedDiet). CLOCK SNPs (rs1801260, rs3749474, rs4580704) and the study procedures were performed in 897 patients from the CORDIOPREV clinical trial. After 12 months of intervention, we found significant gene-diet interactions between rs4580704 SNP and the LF diet. Specifically, major allele carriers C/C displayed a greater decrease in high sensitivity C-reactive protein (p < 0.001) and a significant increase in HDL/apolipoprotein A1 ratio (p = 0.029) than minor G allele carriers (G/G + C/G). No other gene-diet interactions were observed in this research. These results suggest that rs4580704 SNP interacts with the LF diet improving inflammation status and dyslipidemia related with CHD. The shift toward "personalized nutrition" based on gene-nutrient interactions may be suita...Continue Reading

References

Sep 21, 2002·European Journal of Nutrition·Miguel A Martínez-GonzálezJosé M Martín-Moreno
Mar 23, 2004·European Heart Journal·Ramón Arroyo-EspligueroJuan Carlos Kaski
Dec 12, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E M ScottP J Grant
Jan 24, 2008·Circulation·Karen O BadellinoDaniel J Rader
Jun 11, 2008·The American Journal of Clinical Nutrition·Silvia SookoianCarlos Jose Pirola
Oct 23, 2009·The American Journal of Clinical Nutrition·Marta GarauletJose M Ordovas
Jan 28, 2010·The British Journal of Nutrition·Joan D Fernández-BallartJosé M Martín-Moreno
Oct 26, 2010·Chronobiology International·Francesco PortaluppiYvan Touitou
Dec 9, 2010·Circulation. Cardiovascular Quality and Outcomes·Tom G BriffaMatthew Knuiman
Nov 19, 2011·Molecular Nutrition & Food Research·Pablo Perez-MartinezJose Lopez-Miranda
Feb 9, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M GarauletJ M Ordovás
Mar 20, 2012·JAMA : the Journal of the American Medical Association·Quanhe YangFrank B Hu
Jan 15, 2013·Journal of Clinical Lipidology·H Robert SuperkoBrenda C Garrett
Jan 30, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M GarauletF A J L Scheer
Feb 26, 2013·The New England Journal of Medicine·Ramón EstruchUNKNOWN PREDIMED Study Investigators
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 18, 2014·Diabetes & Metabolism·E MauryJ Bass
Jan 22, 2014·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 29, 2014·Physiology & Behavior·Marta Garaulet, Purificación Gómez-Abellán
Apr 17, 2014·Current Medicinal Chemistry·M RizzoM Banach
May 9, 2014·Diabetes Care·Boris WaldmanUNKNOWN FIELD Study Investigators
May 21, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Marcin BarylskiGiuseppe Montalto
Aug 19, 2014·Lancet·Daniel J Rader, G Kees Hovingh
Nov 19, 2014·The New England Journal of Medicine·Anand RohatgiPhilip W Shaul
Dec 21, 2014·The American Journal of Clinical Nutrition·Hassan S DashtiJosé M Ordovás
Jan 21, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M J ParsonsA Caspi
Jan 21, 2015·Progress in Lipid Research·Liam R Brunham, Michael R Hayden
Feb 3, 2015·Brain, Behavior, and Immunity·Kenneth P WrightCharles A Czeisler

❮ Previous
Next ❯

Citations

Nov 11, 2015·Journal of Physiology and Biochemistry·Macarena ValladaresJean-Philippe Chaput
Jun 18, 2016·International Journal of Endocrinology·F J ValenzuelaC Lagunas
Sep 20, 2016·Annals of Physical and Rehabilitation Medicine·Sébastien LacroixAnil Nigam
Oct 6, 2017·Current Cardiology Reports·Kimberly N DoughtyDavid L Katz
Jan 14, 2020·Annual Review of Food Science and Technology·Steven H Zeisel
Jun 2, 2020·The Cochrane Database of Systematic Reviews·Lee HooperC Murray Skeaff
Oct 9, 2020·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Antonio VentriglioDinesh Bhugra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.