Chronic Corticosterone Treatment During Adolescence Has Significant Effects on Metabolism and Skeletal Development in Male C57BL6/N Mice

Endocrinology
Scott A KinleinIlia N Karatsoreos

Abstract

Glucocorticoids are potent modulators of metabolic and behavioral function. Their role as mediators in the "stress response" is well known, but arguably their primary physiological function is in the regulation of cellular and organismal metabolism. Disruption of normal glucocorticoid function is linked to metabolic disease, such as Cushing syndrome. Glucocorticoids are also elevated in many forms of obesity, suggesting that there are bidirectional effects of these potent hormones on metabolism and metabolic function. Adolescence is a time of rapid physical growth, and disruptions during this critical time likely have important implications for adult function. The hypothalamic-pituitary-adrenal axis continues to mature during this period, as do tissues that respond to glucocorticoids. In this work, we investigate how chronic noninvasive exposure to corticosterone affects metabolic outcomes (body weight, body composition, insulin, and glucose homeostasis), as well as changes in bone density in both adult and adolescent male mice. Specifically, we report a different pattern of metabolic effects in adolescent mice compared with adults, as well as an altered trajectory of recovery in adolescents and adults. Together, these data ind...Continue Reading

References

Jul 26, 1986·Lancet·G M FairrisB A Leatherdale
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·H HaunerE F Pfeiffer
Jan 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·T C IancuL Dembo
Jul 1, 1984·Veterinary Pathology·C Fittschen, J E Bellamy
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Feb 6, 1999·Journal of the American Animal Hospital Association·M Schaer, P E Ginn
Feb 12, 2000·Chest·A M WilsonB J Lipworth
Jul 13, 2000·The British Journal of Nutrition·P Björntorp, R Rosmond
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·M C LebrethonM O Savage
Jul 13, 2002·Annals of the New York Academy of Sciences·Ernesto Canalis, Anne M Delany
May 24, 2003·The European Respiratory Journal·D SimN Freezer
May 30, 2003·European Journal of Endocrinology·Sven DiederichWolfgang Oelkers
Jul 18, 2003·Medical and Pediatric Oncology·Qaiser Rehman, Nancy E Lane
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·G ArnaldiM Boscaro
Jul 15, 2004·Annals of the New York Academy of Sciences·Linda Patia Spear
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Helen L StorrMartin O Savage
Apr 6, 2005·Clinical Endocrinology·J H DaviesM O Savage
Jun 15, 2005·Journal of Endocrinological Investigation·S ScommegnaM O Savage
Aug 12, 2006·Pharmacology, Biochemistry, and Behavior·Cheryl M McCormick, Iva Z Mathews
Oct 18, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gary M LeongLynnette K Nieman
Apr 3, 2007·Lancet·George C Patton, Russell Viner
Apr 14, 2007·Current Alzheimer Research·Mary F DallmanMichelle T Foster
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Li F ChanMartin O Savage
Feb 16, 2008·Physiology & Behavior·Arie G Nieuwenhuizen, Femke Rutters
Mar 20, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Subbulaxmi Trikudanathan, Graham T McMahon
Dec 11, 2008·Journal of Bone and Mineral Metabolism·Sun-Il YunYoon-Sok Chung
Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James P WarneMary F Dallman
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·María-José BarahonaSusan M Webb
Oct 6, 2009·Trends in Endocrinology and Metabolism : TEM·Maria-Christina ZennaroBruno Fève
Nov 21, 2009·Trends in Endocrinology and Metabolism : TEM·Mary F Dallman
Oct 16, 2010·Obesity·Jane WardleAndrew Steptoe
Jan 1, 2009·BMJ Case Reports·Maria Francesca MessinaFilippo De Luca
Aug 23, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Keren Mahlab-GuriZev Sthoeger
May 1, 2012·The American Journal of the Medical Sciences·Nicole E AlbertRebecca Dougherty

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Citations

Oct 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristina AnevskaTania Romano
Dec 22, 2019·Frontiers in Neuroendocrinology·Scott A Kinlein, Ilia N Karatsoreos

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