Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells

The Journal of Allergy and Clinical Immunology
P G GibsonN Saltos

Abstract

Chronic cough is a multifactorial condition, which, like asthma, can be associated with eosinophilic airway inflammation. In asthma, airway eosinophilia is believed to be mediated by cytokines such as interleukin-5 and granulocyte-macrophage colony stimulating factor (GM-CSF). The role of these cytokines in chronic cough is unclear. The aim of this study was to examine gene expression for IL-5 and GM-CSF in chronic cough and compare the results with those found in asthma. We studied adults with asthma (n = 12), chronic cough responsive to inhaled corticosteroid (ICS-responsive cough) (n = 9), and chronic cough not responsive to inhaled corticosteroid (non-ICS-responsive cough) (n = 4). Bronchoalveolar lavage (BAL) was performed, and cytokine gene expression was assessed by using a semiquantitative reverse transcriptase polymerase chain reaction. IL-5 mRNA was expressed by BAL cells from nine of 12 asthmatic subjects and six of nine subjects with ICS-responsive chronic cough. IL-5 mRNA was not detected in subjects with non-ICS-responsive chronic cough (zero of four subjects, p < 0.05). GM-CSF mRNA was expressed in BAL cells from seven of 12 asthmatic subjects and six of nine subjects with ICS-responsive cough. GM-CSF mRNA was no...Continue Reading

Citations

Aug 12, 2009·Lung·Christopher E Brightling
Aug 6, 2010·Clinical and Experimental Medicine·Liyan ChenNanshan Zhong
Jul 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Makoto TodokoroAkihiro Morikawa
May 3, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jodie L SimpsonPeter A B Wark
May 31, 2002·The New England Journal of Medicine·Christopher E BrightlingIan D Pavord
Apr 11, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masaki FujimuraJohsuke Hara
Jun 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kevin LooiAnthony Kicic
Apr 25, 2012·Mediators of Inflammation·Beatriz Sastre, Victoria del Pozo
Jun 24, 2000·American Journal of Respiratory and Critical Care Medicine·M Fujimura
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C E BrightlingI D Pavord
Sep 27, 2003·American Journal of Respiratory and Critical Care Medicine·Surinder S BirringIan D Pavord
Mar 27, 2004·American Journal of Respiratory and Critical Care Medicine·Hiroshi KanazawaJunichi Yoshikawa
Dec 26, 2003·American Journal of Respiratory and Critical Care Medicine·Peter G Gibson
Jul 1, 2011·Therapeutic Advances in Chronic Disease·Jaymin B Morjaria, Jack A Kastelik
Dec 1, 2013·Annals of the American Thoracic Society·Ian D Pavord
Apr 5, 2011·Prostaglandins & Other Lipid Mediators·Beatriz SastreJoaquín Sastre
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Nov 16, 2010·Pulmonary Pharmacology & Therapeutics·C E Brightling
Feb 23, 2010·Otolaryngologic Clinics of North America·Dhan Desai, Chris Brightling
Jan 6, 2009·Pulmonary Pharmacology & Therapeutics·Akio NiimiMichiaki Mishima
Apr 22, 2008·Lancet·Kian Fan Chung, Ian D Pavord
Dec 18, 2013·Lung·Akio NiimiPeter V Dicpinigaitis
Mar 13, 2008·Journal of Medical Primatology·J L ChristalJ Jagirdar
Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·Ian D Pavord
Jul 18, 2015·Respiratory Medicine·Matthew J Martin, Tim W Harrison
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·K F Chung
Nov 4, 2000·Expert Opinion on Investigational Drugs·J K Weltman, A S Karim
Mar 20, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Toshiyuki KitaShinji Nakao
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Rekha ChaudhuriNeil C Thomson
Dec 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E BrightlingP Bradding
Mar 17, 2004·Current Opinion in Allergy and Clinical Immunology·Santiago Quirce
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Dow
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FujimuraT Matsuda
Dec 22, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E Brightling, I D Pavord
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Kate J JohnstoneIan A Yang
Apr 13, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Masaki FujimuraKeiichi Iwasa

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