Chronic deep brain stimulation in patients with tardive dystonia without a history of major psychosis

Movement Disorders : Official Journal of the Movement Disorder Society
Hans-Holger CapelleJoachim K Krauss

Abstract

Tardive dystonia usually occurs with a delay after neuroleptic exposure in patients with major psychosis. A subgroup of patients, however, is given such medication for "mild depression" or "neurasthenia." Tardive dystonia, in general, may respond favorably to pallidal deep brain stimulation (DBS). Nevertheless, it remains unclear thus far whether or not similar beneficial outcome is achieved with pallidal DBS in different subgroups of patients with tardive dystonia. Four women (mean age 59 years at surgery) underwent stereotactic pallidal DBS in the frame of an observational study. Tardive dystonia occurred secondary to medication with fluspirilene and haloperidol, and injection of long-acting depot neuroleptics prescribed for mild depression or "nervousness." Assessment included the Burke-Fahn-Marsden (BFM) scale preoperatively and at 12 months follow-up. Extended follow-up was available at a mean of 27.3 months postoperatively (range 16-36 months). There were no surgically related complications. All 4 patients experienced sustained statistically significant benefit from pallidal DBS. Mean improvement at 12 months was 77% for the BFM motor score (range, 45-91%; P = 0.043), and 84% at the last available follow-up (range, 70-91%...Continue Reading

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Citations

Apr 2, 2011·Current Treatment Options in Neurology·Naomi Lubarr, Susan Bressman
Nov 17, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Marie VidailhetEmmanuel Roze
Apr 20, 2014·Current Neurology and Neuroscience Reports·D Cristopher Bragg, Nutan Sharma
Jan 23, 2016·Neurology·Hélène Pouclet-CourtemanchePhilippe Damier
Dec 6, 2011·Expert Opinion on Therapeutic Targets·Valerie B ThompsonEllen J Hess
Nov 1, 2011·Expert Opinion on Medical Diagnostics·Stefania LalliAlberto Albanese
Nov 2, 2013·Neurologic Clinics·Jeffrey L Waugh, Nutan Sharma
Nov 23, 2013·Neurosurgery Clinics of North America·Kelly A MillsJill L Ostrem
Mar 13, 2016·Neurologia i neurochirurgia polska·Michał Sobstyl, Mirosław Ząbek
Mar 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Wichmann, Mahlon R DeLong
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Laurie J OzeliusSusan B Bressman
Aug 7, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·James T TeoKailash Bhatia
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Apr 3, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·J J FitzGeraldT Z Aziz
Oct 27, 2012·Parkinsonism & Related Disorders·Meredith A SpindlerJohn E Duda
Apr 24, 2017·Stereotactic and Functional Neurosurgery·Andreas WlochJoachim K Krauss
Jan 14, 2017·Frontiers in Psychiatry·Ryoma MorigakiSatoshi Goto
Mar 28, 2015·Movement Disorders Clinical Practice·Christoph SchraderJoachim K Krauss
Nov 27, 2015·Movement Disorders Clinical Practice·Marc E WolfJoachim K Krauss
Aug 4, 2021·Acta neurochirurgica·Joachim RungeJoachim K Krauss

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