Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.

The Journal of Biological Chemistry
Jessica A WilliamsWen-Xing Ding

Abstract

We previously demonstrated that pharmacological induction of autophagy protected against acetaminophen (APAP)-induced liver injury in mice by clearing damaged mitochondria. However, the mechanism for removal of mitochondria by autophagy is unknown. Parkin, an E3 ubiquitin ligase, has been shown to be required for mitophagy induction in cultured mammalian cells following mitochondrial depolarization, but its role in vivo is not clear. The purpose of this study was to investigate the role of Parkin-mediated mitophagy in protection against APAP-induced liver injury. We found that Parkin translocated to mitochondria in mouse livers after APAP treatment followed by mitochondrial protein ubiquitination and mitophagy induction. To our surprise, we found that mitophagy still occurred in Parkin knock-out (KO) mice after APAP treatment based on electron microscopy analysis and Western blot analysis for some mitochondrial proteins, and Parkin KO mice were protected against APAP-induced liver injury compared with wild type mice. Mechanistically, we found that Parkin KO mice had decreased activated c-Jun N-terminal kinase (JNK), increased induction of myeloid leukemia cell differentiation protein (Mcl-1) expression, and increased hepatocyte...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H Jaeschke, J R Mitchell
Mar 5, 2003·Journal of Cell Science·Bradley W Doble, James R Woodgett
Apr 22, 2004·Genes, Chromosomes & Cancer·Fang WangDavid I Smith
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Xing DingXiao-Ming Yin
Jul 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Guang-Ho ChaKyoung Sang Cho
Jul 13, 2006·Gastroenterology·Basuki K GunawanNeil Kaplowitz
Mar 17, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Calivarathan LatchoumycandaneUrs A Boelsterli
Aug 29, 2007·Clinics in Liver Disease·Anne M Larson
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rachel L SchweersPaul A Ney
Feb 19, 2008·The Journal of Biological Chemistry·Huafeng ZhangGregg L Semenza
Mar 14, 2008·Current Molecular Medicine·Matthew R Warr, Gordon C Shore
Jul 16, 2008·Autophagy·Ji Zhang, Paul A Ney
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Apr 21, 2009·Autophagy·Derek NarendraRichard J Youle
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cristofol Vives-BauzaSerge Przedborski
Jan 26, 2010·Nature Cell Biology·Sven GeislerWolfdieter Springer
Feb 4, 2010·PLoS Biology·Derek P NarendraRichard J Youle
Feb 8, 2011·Human Molecular Genetics·Nickie C ChanDavid C Chan
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong-Min NiWen-Xing Ding
Apr 12, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hong-Min NiWen-Xing Ding
Aug 25, 2012·Molecular Pharmacology·Manju SharmaAnja Jaeschke
Sep 5, 2012·Biological Chemistry·Wen-Xing Ding, Xiao-Ming Yin
Sep 8, 2012·International Journal of Cell Biology·Fulvio ReggioriAnne Simonsen
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun
Oct 26, 2012·The Journal of Biological Chemistry·Wen-Xing DingXiao-Ming Yin
Mar 7, 2013·Pharmaceutical Research·Mitchell R McGill, Hartmut Jaeschke
Jun 4, 2013·Antioxidants & Redox Signaling·Katherine R Parzych, Daniel J Klionsky
Jun 19, 2013·Autophagy·Mark J CzajaXiao-Ming Yin

❮ Previous
Next ❯

Citations

Nov 28, 2015·Journal of Molecular and Cellular Cardiology·Gerald W Dorn
Dec 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jessica A Williams, Wen-Xing Ding
Mar 20, 2016·Biochimica Et Biophysica Acta·Gerald W Dorn
May 12, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yuan LiWen-Xing Ding
Jan 18, 2017·Experimental Biology and Medicine·Jessica A WilliamsWen-Xing Ding
Jul 14, 2017·PLoS Genetics·Mohamed A El-Brolosy, Didier Y R Stainier
Apr 24, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Xiaojuan ChaoWen-Xing Ding
Nov 10, 2018·FEBS Letters·Simin ZhengJayanta Chaudhuri
Jul 15, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jessica A WilliamsWen-Xing Ding
Jan 23, 2020·The Journal of Cell Biology·Alexander SchulzMarc Hammarlund
Oct 24, 2019·Archives of Toxicology·Hartmut JaeschkeWen-Xing Ding
Oct 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yingqing ChenHun Taeg Chung
May 30, 2020·Journal of Cellular and Molecular Medicine·Irene CrespoMaría Jesús Tuñón
Jun 13, 2020·Archives of Toxicology·Qiuhua TanZhengquan Su
Oct 5, 2017·Biological Chemistry·Jessica A Williams, Wen-Xing Ding
Jun 8, 2018·Archives of Toxicology·Shulin ShanFuyong Song
Apr 5, 2020·Cells·Xiaowen MaWen-Xing Ding
Jan 4, 2017·Alcoholism, Clinical and Experimental Research·Yuan Li, Wen-Xing Ding
Jun 6, 2018·Frontiers in Pharmacology·Anna MolesJose C Fernandez-Checa
Apr 11, 2018·World Journal of Gastroenterology : WJG·Hui YeFrancisco Javier Cubero
May 21, 2019·Cellular and Molecular Gastroenterology and Hepatology·Paul J WrightonWolfram Goessling
Mar 24, 2020·Seminars in Cancer Biology·Mohd IshaqShrawan K Singh
Dec 24, 2020·International Journal of Molecular Sciences·Layla ShojaieLily Dara
Dec 4, 2020·Toxicology and Applied Pharmacology·Peiwen ZhangXu Chen
Jun 20, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hartmut JaeschkeAnup Ramachandran
Jun 15, 2021·Molecular Aspects of Medicine·Hui QianWen-Xing Ding
Oct 9, 2021·Current Pharmaceutical Design·Li-Ping YuXing-Xin Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

© 2022 Meta ULC. All rights reserved