Chronic disease in the Mojave desert tortoise: Host physiology and recrudescence obscure patterns of pathogen transmission

Ecology and Evolution
F C SandmeierK W Hunter

Abstract

A seminatural, factorial-design experiment was used to quantify dynamics of the pathogen Mycoplasma agassizii and upper respiratory tract disease in the Mojave desert tortoise (Gopherus agassizii) over 2 years. Groups of initially healthy animals were separated into serologically positive (seropositive), seronegative, and artificially infected groups and paired into 23 pens. We found no evidence of long-term immune protection to M. agassizii or of immunological memory. Initially seronegative, healthy tortoises experienced an equal amount of disease when paired with other seronegative groups as when paired with seropositive and artificially infected groups-suggesting that recrudescence is as significant as transmission in introducing disease in individuals in this host-pathogen system. Artificially infected groups of tortoises showed reduced levels of morbidity when paired with initially seronegative animals-suggesting either a dilution effect or a strong effect of pathogen load in this system. Physiological dynamics within the host appear to be instrumental in producing morbidity, recrudescence, and infectiousness, and thus of population-level dynamics. We suggest new avenues for studying diseases in long-lived ectothermic vert...Continue Reading

References

Oct 1, 1994·Infection and Immunity·M B BrownE R Jacobson
Nov 1, 1996·Veterinary Microbiology·B RentierS Schoonbroodt
Dec 1, 1996·Revue Scientifique Et Technique·L Stipkovits, I Kempf
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S RazinY Naot
Mar 29, 2003·Physiological Reviews·Shlomo Rottem
Oct 19, 2004·Clinical Microbiology Reviews·Ken B Waites, Deborah F Talkington
Jan 6, 2005·Springer Seminars in Immunopathology·Nicole BaumgarthLeonore A Herzenberg
Apr 21, 2006·Ecology Letters·F KeesingR S Ostfeld
Feb 16, 2010·The Journal of Experimental Biology·L M ZimmermanR M Bowden
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cheryl J BriggsVance T Vredenburg
Aug 26, 2010·The Journal of Animal Ecology·Daniel M TompkinsSandra Telfer
Feb 10, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chinyere K OkoroMelita A Gordon
Jun 26, 2012·Journal of Theoretical Biology·Paul J Hurtado
Apr 25, 2014·Integrative and Comparative Biology·Franziska C Sandmeier, Richard C Tracy

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Citations

Nov 27, 2018·Royal Society Open Science·Chava L WeitzmanC Richard Tracy
Nov 7, 2020·The Journal of Experimental Biology·Laura M Zimmerman

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Methods Mentioned

BETA
PCR
ELISA
blood drawn
ELISAs
electrophoresis
flow cytometry

Software Mentioned

JMP Pro

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