PMID: 8614268Jan 1, 1996Paper

Chronic effect of hyperprolactinemia on blood glucose and lipid levels in mice

Life Sciences
M MatsudaS Kawashima

Abstract

We studied the chronic effects of hyperprolactinemia, induced by ectopic pituitary grafting, on blood glucose and lipid levels in adult male mice. For one year after pituitary grafting, we measured the blood levels of prolactin, growth hormone (GH), insulin, glucose and free fatty acid (FFA) at various intervals. The graft caused consistent hyperprolactinemia without changes in the serum GH levels. Hypoglycemia developed at 1 and 3 months after grafting but was not accompanied by any changes of the serum insulin levels. Thereafter, the blood glucose and serum insulin levels began to increase in the pituitary-grafted (PG) mice, and at 12 months after the operation, both levels became significantly higher in PG mice than controls. The serum FFA levels and the weight of epididymal fat bodies were significantly lower in PG mice than controls from 3-12 months after the grafting. Thus, hyperprolactinemia leads to persistent hypolipidemia and biphasic changes in the blood glucose level.

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Feb 1, 1994·European Journal of Endocrinology·M MatsudaS Kawashima

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Citations

Jul 10, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·A N OrlovaO V Smirnova
Jul 10, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·A N OrlovaA N Smirnov
Nov 18, 2006·Journal of Clinical Psychopharmacology·Oliver D HowesLyn S Pilowsky
Dec 7, 2007·Endocrine Reviews·Nira Ben-JonathanElizabeth W LaPensee
Mar 7, 2006·Trends in Endocrinology and Metabolism : TEM·Nira Ben-JonathanChristopher R LaPensee
Apr 2, 2009·The Journal of Toxicological Sciences·Keiko OseYasuyoshi Okuno
Oct 28, 1999·Endocrinology·O GualilloC Diéguez
Jul 1, 2006·Endocrinology·Christopher R LaPenseeNira Ben-Jonathan
Jan 20, 2021·Journal of Neuroendocrinology·Felicitas Lopez-VicchiDamasia Becu-Villalobos

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