PMID: 26817209Jan 29, 2016Paper

Chronic Effect of Thunbergia laurifolia Extract and Cocaine in Rats Using Behavior Model of Addiction

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Watchareewan ThongsaardCharles A Marsden

Abstract

Thunbergia laurifolia Linn. (TL) is a herbal medicine which has been used as a component of a mixture ofcrude extracts to treat drug addicted patients. TL extract was reported to increase dopamine levels significantly in the rat brain both in vitro and in vivo studies similar to that seen with cocaine and TL stimulated in the same brain area that amphetamine stimulated. The study aims to investigate whether long term treatment with TL can cause addiction or not by comparing with known addicted drug, cocaine, using the conditioned place preference test. Chronic oral administration (30 days) of crude water extract of TL (1 and 10 g/kg, orally) and cocaine (1 mg/kg, orally) were performed to determine the alteration of addiction behavior using a conditioned place preference (CPP) test. Rats received chronic treatment ofcocaine became addicted. While, both doses of TL (1 and 10 g/kg, orally) did not cause significantly in the time spent in both compartment between pre- and post-drug treatment. When treated long-term and tested with CPP test of addiction, rats received chronic treatment ofcocaine became addicted. On the other hand, both doses ofcrude water extract of TL (1 and 10 g/kg, orally) did not cause significant changed in th...Continue Reading

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.