Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Shaokuan FangXin-Min Li

Abstract

Venlafaxine, a novel antidepressant, inhibits serontonin and norepinephrine reuptake in the presynaptic cleft. Unlike typical selective serontonin reuptake inhibitors (SSRIs), venlafaxine may have modulatory effects on nerve terminals and neuronal plasticity. Our preliminary data found that 5 mg.kg-1.d-1 of venlafaxine treatment prevented decreased synaptophysin (SYP) in the hippocampus, which results from chronic restrained stress in the rat model. The present study investigates whether venlafaxine regulates alterations of synaptophysin and neuronal cell adhesion molecule (NCAM) in a post-stroke depression mouse model. We compared the expression level of SYP and NCAM in the hippocampus of global cerebral ischemic (GCI) mice treated with different doses of venlafaxine using immunohistological and Western blot analysis. Pre-treatment with intraperitoneal injection of venlafaxine (2.5 and 5.0 mg.kg-1.d-1) for 14 days significantly prevented the decrease of SYP in the hilus area of the hippocampus in vehicle-treated GCI mice. NCAM was significantly higher in the hippocampus of vehicle-treated GCI mice, and pretreatment with venlafaxine prevented alterations of NCAM, with the high-dose venlafaxine group comparable with vehicle-sham...Continue Reading

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Citations

Sep 7, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mingyue FanPeiyuan Lu
Aug 12, 2014·Psychiatry Investigation·Mi-Gyung LeeJoonho Choi
Nov 30, 2016·Pharmacology, Biochemistry, and Behavior·Eva M MarcoMaría-Paz Viveros
Jun 19, 2012·Psychiatry Investigation·Mi Ran ChoiYoung Gyu Chai
Feb 21, 2014·Pharmacological Reports : PR·Krzysztof WędzonyMarzena Maćkowiak
Sep 2, 2020·Cell Stress & Chaperones·S DemyanenkoD G Garbuz
Nov 26, 2013·Molecular Medicine Reports·Tianjun WangMingyue Fan
Apr 12, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Wen-Guang XiaJuan Wang

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