Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders

Journal of Neurosurgery
A L BenabidA Benazzouz

Abstract

Tremor was suppressed by test stimulation of the thalamic ventralis intermedius (VIM) nucleus at high frequency (130 Hz) during stereotaxy in nonanesthetized patients suffering from Parkinson's disease or essential tremor. Ventralis intermedius stimulation has since been used by the authors over the last 8 years as a treatment in 117 patients with movement disorders (80 cases of Parkinson's disease, 20 cases of essential tremor, and 17 cases of various dyskinesias and dystonias including four multiple sclerosis). Chronic electrodes were stereotactically implanted in the VIM and connected to a programmable stimulator. Results depend on the indication. In Parkinson's disease patients, tremor, but not bradykinesia and rigidity, was selectively suppressed for as long as 8 years. Administration of L-Dopa was decreased by more than 30% in 40 Parkinson's disease patients. In essential tremor patients, results were satisfactory but deteriorated with time in 18.5% of cases, mainly for patients who presented an action component of their but deteriorated with time in 18.5% of cases, mainly for patients who presented an action component of their tremor. In other types of dyskinesias (except multiple sclerosis), results were much less favor...Continue Reading

References

Mar 1, 1979·Journal of Neurosurgery·C Ohye, H Narabayashi
Jan 1, 1991·British Journal of Neurosurgery·P V MarksJ R Gleave
Nov 1, 1990·Journal of Neurosurgery·W P Cheshire, A L Ehle
Feb 1, 1986·Electroencephalography and Clinical Neurophysiology·S Raeva
Jan 1, 1989·Stereotactic and Functional Neurosurgery·S TothZ Toth
Jan 1, 1989·European Neurology·H Narabayashi
Jul 1, 1988·Neurobiology of Aging·B CorainP Zatta
Sep 1, 1986·Journal of Neurosurgery·Y NagasekiC Ohye
Jan 1, 1971·Zeitschrift für Neurologie·G SchaltenbrandB Rümler
Jun 1, 1966·Electroencephalography and Clinical Neurophysiology·W W AlbertsE W Wright
Dec 1, 1974·Journal of Neurosurgery·J E AdamsH L Fields
Jun 1, 1974·Journal of the Neurological Sciences·C OhyeH Narabayashi
Jan 1, 1970·Experimental Brain Research·C OhyeL J Poirier
Dec 1, 1971·Canadian Journal of Physiology and Pharmacology·Y Lamarre, L A Mercier
Jan 1, 1966·Journal of Neurosurgery·L Laitinen
Feb 16, 1967·The New England Journal of Medicine·G C CotziasL M Schiffer
Dec 1, 1983·Brain : a Journal of Neurology·J AndrewM J Harrison
Jan 1, 1983·Applied Neurophysiology·R R TaskerL W Organ
Jan 1, 1983·Applied Neurophysiology·O J Andy
Jan 1, 1980·Acta neurochirurgica. Supplementum·G MazarsC Cioloca
Jan 1, 1982·Applied Neurophysiology·F Mundinger, H Neumüller
Jan 1, 1982·Applied Neurophysiology·R R TaskerP Hawrylyshyn
Jan 1, 1982·Applied Neurophysiology·C OhyeH Nakajima
Jan 1, 1982·Applied Neurophysiology·S J LarsonN Wetzel
Oct 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·A L BurleighJ G Nutt

❮ Previous
Next ❯

Citations

Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·W C KollerR Pahwa
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·A Minguez-CastellanosJ M Martin-Linares
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·M M PinterH Binder
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·C DromeyA M Lozano
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·R PahwaW C Koller
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·M I Hariz, F Johansson
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E D LouisA E Lang
Mar 4, 1998·Annals of Neurology·P KrackA L Benabid
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Xuguang LiuJohn F Stein
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJerry Vitek
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Dipankar NandiJohn F Stein
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Alim L BenabidPierre Pollak
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Pierre PollakAlim-Louis Benabid
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Johannes D SpeelmanD Andries Bosch
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Ira M GaronzikFrederick A Lenz
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Pierre PollakAlim-Louis Benabid
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·G WihlH J Freund
Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·T TrottenbergA Kupsch
Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·D MutaS Mita
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J P HubbleW C Koller
Sep 26, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A StrafellaA E Lang
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·G M HarizM Lindberg
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Apr 11, 2009·Der Nervenarzt·R HilkerUNKNOWN German Deep Brain Stimulation Association
Oct 22, 2009·Experimental Brain Research·Tristan M StaniValerie C Anderson
Feb 24, 2007·Journal of Neurology·Marcus KochJacques De Keyser
Jul 30, 2009·Journal of Neurology·Frandy SusatiaMichael S Okun
Jul 10, 2007·Biological cybernetics·William S AndersonPiotr J Franaszczuk
Aug 24, 2004·Cell and Tissue Research·Sorin BreitAlim-Louis Benabid
Mar 31, 2011·Journal of Neural Transmission·Erlick A C PereiraTipu Z Aziz
May 8, 2013·Journal of Neural Transmission·Ines A HeberMartin Kronenbuerger
Dec 18, 2012·Medical & Biological Engineering & Computing·Thi Kim Thoa NguyenGeorges Gielen
Aug 1, 2012·Cognitive Neurodynamics·Markus Schütt, Jens Christian Claussen
Aug 22, 2003·Current Neurology and Neuroscience Reports·Helen Bronte-Stewart
Jun 26, 2004·Current Neurology and Neuroscience Reports·Kelly E Lyons, Rajesh Pahwa
May 20, 2009·The Cerebellum·Martin KronenbuergerDagmar Timmann
Apr 12, 2011·The Cerebellum·Hideto Miwa, Tomoyoshi Kondo
Aug 7, 2004·Clinical Neurology and Neurosurgery·Atsushi UmemuraGordon H Baltuch
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Angelo InsolaMassimiliano Valeriani
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ritsuko HanajimaPeter Ashby
Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
May 12, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
Dec 10, 2003·Current Opinion in Neurobiology·Alim Louis Benabid
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hong Yu, Joseph S Neimat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.