PMID: 2110970Jun 1, 1990Paper

Chronic electroconvulsive seizures down-regulate expression of the immediate-early genes c-fos and c-jun in rat cerebral cortex

Journal of Neurochemistry
S M WinstonR S Duman

Abstract

Acute seizures and other stimuli that increase neuronal activity cause a rapid induction of the immediate-early genes c-fos and c-jun, also referred to as nuclear proto-oncogenes, in the nervous system. In the present study, rats were administered one or more electroconvulsive seizures (ECS) and the responsiveness of c-fos and c-jun to an acute, "test" seizure was examined. Four hours after a single ECS, the induction of c-fos mRNA by a test seizure was blocked, in agreement with earlier findings, but by 18 h the levels of c-fos mRNA could be reinduced by the test seizure, suggesting that 1 day is sufficient to "reset" the responsiveness of this system. However, it was found that chronic, daily ECS treatments resulted in a time-dependent decrease in the expression of c-fos mRNA in response to a test seizure administered 18 h after the last daily ECS; this effect was maximal after 8-10 days of treatment, at which time the induction of c-fos mRNA by the test seizure was blocked dramatically. Chronic ECS also blocked the induction of c-jun in response to an acute, test seizure. The effect of chronic ECS on levels of Fos protein was also investigated. It was found that basal levels of Fos protein were reduced after chronic (10 days...Continue Reading

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Citations

Apr 1, 1997·Synapse·S MorinobuR S Duman
Aug 10, 2012·Journal of Neural Transmission·Julien Braga CalaisElida Benquique Ojopi
Apr 25, 2006·Cellular and Molecular Neurobiology·Torsten M MadsenJens D Mikkelsen
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Jan 7, 2016·Annals of Clinical and Translational Neurology·Meaghan MorrisLennart Mucke
Jan 15, 2005·Biochemical and Biophysical Research Communications·Woong SunHyun Kim

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