Abstract
Hypereosinophilic syndrome (HES) was diagnosed in December 2000 in a 43-year-old man on the basis of persistent eosinophilia (11.7 x 10(9)/L) and a normal karyotype of the bone marrow cells. He had developed intra-abdominal non-Hodgkin's lymphoma and in 1992 had received 3 courses of combination chemotherapy with doxorubicin (Adriamycin), cyclophosphamide, vincristine, methotrexate, bleomycin, and prednisolone. The patient was orally given prednisolone (10 mg/day) and cyclophosphamide (50 mg/day) as HES treatment without a subsequent improvement of the eosinophilia. In May 2003, anemia (hemoglobin, 7.9 g/dL) and thrombocytopenia (65 x 10(9)/L) manifested with progressive eosinophilia (21.0 x 10(9)/L) and a small number of blasts. The patient became febrile and was admitted in July 2003. Cytogenetic reexamination of the bone marrow cells disclosed the deletion of 4q12, indicating the presence of a fusion of the Fip1-like 1 (FIP1L1) gene to the plateletderived growth factor receptor alpha (PDGFRalpha) gene and consequently the clonal nature of his hematopoietic cells. DNA sequence analysis demonstrated that the breakpoints of the FIP1L1 and PDGFRalpha genes were present in exon 9 and exon 12, respectively. Treatment with imatinib...Continue Reading
References
Jan 1, 1975·Medicine·M J ChusidS M Wolff
Feb 24, 1994·The New England Journal of Medicine·E CoganM Goldman
Jun 25, 1998·Leukemia & Lymphoma·R C Aguiar
Jan 13, 2000·Histopathology·N L HarrisC D Bloomfield
Jun 6, 2002·Lancet·Gerald J GleichJoseph H Butterfield
Jul 20, 2002·Leukemia Research·Patricia AultHagop Kantarjian
Aug 16, 2002·The New England Journal of Medicine·Jane F ApperleyJohn M Goldman
Dec 31, 2002·Blood·Animesh PardananiAyalew Tefferi
Feb 22, 2003·Blood·Jorge CortesHagop Kantarjian
Mar 28, 2003·The New England Journal of Medicine·Jan CoolsD Gary Gilliland
Apr 5, 2003·Blood·Amy D KlionThomas B Nutman
Jul 9, 2003·British Journal of Haematology·Barbara J Bain
Sep 25, 2003·Blood·Amy D KlionThomas B Nutman
Dec 13, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Ziad SalemAli Bazarbachi
Dec 17, 2003·Current Opinion in Hematology·Jan CoolsD Gary Gilliland
Feb 20, 2004·Leukemia·P VandenbergheP Marynen
Feb 27, 2004·Annals of Hematology·Norbert FrickhofenAndreas Hochhaus
Mar 24, 2004·Leukemia Research·Yuko IshiiKazuma Ohyashiki
May 19, 2004·Archives of Dermatology·Kathleen J SmithHenry Skelton
Aug 6, 2004·International Journal of Hematology·D TanP Tan
Aug 2, 2007·Haematologica·Michele BaccaraniGiovanni Martinelli
Sep 18, 2007·Immunology and Allergy Clinics of North America·Barbara J Bain, Sarah H Fletcher
Citations
Aug 19, 2007·Annals of Hematology·Akiko SadaUNKNOWN Japanese Elderly Leukemia and Lymphoma Study Group
Mar 20, 2015·Internal Medicine·Danijela LekovicIvo Elezovic
Jul 22, 2006·British Journal of Haematology·Hiroaki OhnishiTakashi Watanabe
Jan 16, 2008·Oral Diseases·M A IonescuA Janin
Dec 25, 2016·Critical Reviews in Oncology/hematology·Kwaku Appiah-KubiYongchang Chen
Nov 30, 2006·Current Opinion in Hematology·Sarah Fletcher, Barbara Bain
Oct 18, 2007·Current Opinion in Pulmonary Medicine·Tatjana Peros-Golubicić, Silvana Smojver-Jezek