Chronic eosinophilic leukemia with the FIP1L1-PDGFRalpha fusion gene in a patient with a history of combination chemotherapy

International Journal of Hematology
Yasuhiro TanakaTakayuki Takahashi

Abstract

Hypereosinophilic syndrome (HES) was diagnosed in December 2000 in a 43-year-old man on the basis of persistent eosinophilia (11.7 x 10(9)/L) and a normal karyotype of the bone marrow cells. He had developed intra-abdominal non-Hodgkin's lymphoma and in 1992 had received 3 courses of combination chemotherapy with doxorubicin (Adriamycin), cyclophosphamide, vincristine, methotrexate, bleomycin, and prednisolone. The patient was orally given prednisolone (10 mg/day) and cyclophosphamide (50 mg/day) as HES treatment without a subsequent improvement of the eosinophilia. In May 2003, anemia (hemoglobin, 7.9 g/dL) and thrombocytopenia (65 x 10(9)/L) manifested with progressive eosinophilia (21.0 x 10(9)/L) and a small number of blasts. The patient became febrile and was admitted in July 2003. Cytogenetic reexamination of the bone marrow cells disclosed the deletion of 4q12, indicating the presence of a fusion of the Fip1-like 1 (FIP1L1) gene to the plateletderived growth factor receptor alpha (PDGFRalpha) gene and consequently the clonal nature of his hematopoietic cells. DNA sequence analysis demonstrated that the breakpoints of the FIP1L1 and PDGFRalpha genes were present in exon 9 and exon 12, respectively. Treatment with imatinib...Continue Reading

References

Jun 6, 2002·Lancet·Gerald J GleichJoseph H Butterfield
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Jul 9, 2003·British Journal of Haematology·Barbara J Bain
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Citations

Jan 16, 2008·Oral Diseases·M A IonescuA Janin
Dec 25, 2016·Critical Reviews in Oncology/hematology·Kwaku Appiah-KubiYongchang Chen
Nov 30, 2006·Current Opinion in Hematology·Sarah Fletcher, Barbara Bain
Oct 18, 2007·Current Opinion in Pulmonary Medicine·Tatjana Peros-Golubicić, Silvana Smojver-Jezek

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