PMID: 11328192May 1, 2001Paper

Chronic epilepsy with complex partial seizures is not always medically intractable--a long-term observational study

Acta Neurologica Scandinavica
E TrinkaGerhard Bauer

Abstract

To study the prognosis of patients with complex partial seizures (CPS) with or without simple partial (SPS) and secondarily generalized tonic-clonic seizures (GTCS) and to analyze the factors related to the degree of medical responsiveness. A total of 266 adult patients with CPS were included in a hospital based observational survey with a follow-up of 2 to 25 years. Clinical characteristics, seizure frequency, electroencephalography (EEG), cerebral computed tomography (CCT) and magnetic resonance imaging (MRI) findings were analyzed. Patients were categorized according to their degree of medical responsiveness into one of three groups: seizure free, improved control (>50% seizure reduction) and poor control. Mean age at follow-up was 44.7 years (SD 14.7, range 19-93). Mean age at seizure onset was 18.1 years (SD 14.7, median 15, range 1-79). Complete seizure control was achieved in 40%, improved seizure control in 36% and poor seizure control in 24%. Patients entered remission after a mean period of 15.7 years (SD 12.6, median 13, range 1-54) of active epilepsy. A third of all seizure-free patients were still in remission 6.1 years (SD 5.3, median 3.5, range 1-18) after discontinuation of antiepileptic drugs (AED). Patients wi...Continue Reading

Citations

Jul 2, 2014·Epilepsy & Behavior : E&B·Kenneth D LaxerSelim R Benbadis
Jul 14, 2007·Pediatric Neurology·Zhiping WangXiaoqing Song
Jul 14, 2007·Clinical Neurology and Neurosurgery·Andrew C F HuiK S Wong
Dec 20, 2005·Acta Neurologica Scandinavica. Supplementum·E Trinka
Feb 22, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·C Castaño De La MotaM L Ruiz-Falcó Rojas

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