PMID: 2504891Aug 1, 1989Paper

Chronic epileptic foci in vitro in hippocampal slices from rats with the tetanus toxin epileptic syndrome

Journal of Neurophysiology
J G Jefferys

Abstract

1. Minute doses of tetanus toxin were injected into the hippocampi of rats, under pentobarbitone anesthesia, to induce a chronic experimental epilepsy. The effects of this treatment were studied in vitro in hippocampal slices prepared 1-60 days after injection. 2. Epileptic activity was preserved in these slices in vitro, closely resembling that seen in vivo. Epileptiform afterdischarges were evoked by stimulation after survival times of greater than or equal to 3 days from injection. Spontaneous synchronous epileptic discharges were recorded from 7 days after injection. Both kinds of epileptiform activity were found with survival times up to 36 days but not beyond 44 days. This time course resembles the waxing and waning of the epileptic syndrome in vivo. 3. Two distinct types of spontaneous burst were seen. The first was a simple burst lasting 100-300 ms, reminiscent of the "interictal spike" of the clinical electroencephalogram. The second was much more prolonged, lasting several seconds. It consisted of a simple burst followed by a series of discrete afterbursts at 3-6/s and resembled the early stages of an epileptic seizure. Both types of burst were associated with slow field potentials that were positive at the cell-body ...Continue Reading

Citations

Oct 1, 1991·The European Journal of Neuroscience·K BrenerM J Gutnick
Jan 1, 1995·Acta Neuropathologica·J MitchellL E Sundstrom
Dec 6, 2002·Journal of Neurophysiology·G T Finnerty, J G R Jefferys
Sep 29, 2009·Clinical EEG and Neuroscience·D T Barkmeier, J A Loeb
Sep 1, 1996·Epilepsia·R D TraubJ G Jefferys
Nov 11, 2009·Journal of Computational Neuroscience·Ata Ozkaya, Mehmet Korürek
Apr 20, 2010·Brain : a Journal of Neurology·Premysl JiruskaJohn G R Jefferys
Feb 1, 1995·Italian Journal of Neurological Sciences·J G JefferysJ Mellanby
Jan 21, 2014·Brain Structure & Function·Alex S FerecskóJohn G R Jefferys

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