PMID: 8610145Apr 2, 1996Paper

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

Proceedings of the National Academy of Sciences of the United States of America
J M ArbeitD Hanahan

Abstract

High-risk human papillomaviruses (HPVs), including type 16, have been identified as factors in cervical carcinogenesis. However, the presence and expression of the virus per se appear to be insufficient for carcinogenesis. Rather, cofactors most likely are necessary in addition to viral gene expression to initiate neoplasia. One candidate cofactor is prolonged exposure to sex hormones. To examine the possible effects of estrogen on HPV-associated neoplasia, we treated transgenic mice expressing the oncogenes of HPV16 under control of the human keratin-14 promoter (K14-HPV16 transgenic mice) and nontransgenic control mice with slow release pellets of 17beta-estradiol. Squamous carcinomas developed in a multistage pathway exclusively in the vagina and cervix of K14-HPV16 transgenic mice. Estrogen-induced carcinogenesis was accompanied by an incremental increase in the incidence and distribution of proliferating cells solely within the cervical and vaginal squamous epithelium of K14-HPV16 mice. Expression of the HPV transgenes in untreated transgenic mice was detectable only during estrus; estrogen treatment resulted in transgene expression that was persistent but not further upregulated, remaining at low levels at all stages of c...Continue Reading

References

Sep 30, 1991·International Journal of Cancer. Journal International Du Cancer·A HildesheimW E Rawls
Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·K J AubornH L Bradlow
Jan 1, 1990·Pharmacology & Therapeutics·J E Hart
Aug 1, 1989·The Journal of General Virology·S Mitrani-RosenbaumR Tur-Kaspa
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·A SchneiderL Gissmann
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies

❮ Previous
Next ❯

Citations

Oct 16, 2012·Hormones & Cancer·Sang-Hyuk ChungPaul F Lambert
Mar 1, 2012·Journal of Physiology and Biochemistry·Mirja RotinenIgnacio Encío
Nov 26, 2002·Virus Research·Xavier CastellsaguéNubia Muñoz
Mar 1, 1997·Clinics in Dermatology·J J Carter, D A Galloway
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D HanahanJ Arbeit
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G J KelloffP Greenwald
Jan 7, 2006·Nature Reviews. Cancer·Karin E de VisserLisa M Coussens
Jul 2, 2010·Nature Reviews. Cancer·Cary A Moody, Laimonis A Laimins
Mar 27, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M MoodleyC S Herrington
Mar 14, 2002·Journal of the American Geriatrics Society·G F SawayaJ Mandelblatt
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sang-Hyuk Chung, Paul F Lambert
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael HerfsChristopher P Crum
Apr 16, 2003·The Journal of Experimental Medicine·Dylan DanielDouglas Hanahan
Jan 29, 1999·Annals of Surgery·J M Arbeit, R Hirose
Dec 14, 2007·Sexually Transmitted Diseases·Yudira SotoUlrich R Hengge
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M RuutuS Syrjänen
Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E M IbrahimM Wells
Oct 14, 2004·Journal of Virology·Karl MüngerKyungwon Huh
Jun 20, 1998·Sexually Transmitted Infections·C Sonnex
Oct 29, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Daniel W SepkovicH Leon Bradlow
Sep 3, 2004·The Journal of Clinical Investigation·Enrico GiraudoDouglas Hanahan
Apr 10, 2012·The Journal of Clinical Investigation·Federica MaioneEnrico Giraudo
Mar 25, 2006·Molecular Medicine·Mei QiKaren J Auborn
Apr 19, 2011·Clinical Medicine Insights. Oncology·Jimmy T EfirdChristopher J Phillips
Apr 1, 2006·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jung Kyu ParkSoon Do Cha
Aug 15, 2013·Cancer Letters·Scott A Read, Mark W Douglas
Feb 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tiffany Brake, Paul F Lambert
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M R YoungN Colburn
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G J KelloffP Greenwald
Apr 26, 2014·Biological Trace Element Research·Jing JiYueling Wang
Jan 5, 2011·FEBS Letters·Kari Vaahtomeri, Tomi P Mäkelä

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.