PMID: 9422366Jan 9, 1998Paper

Chronic ethanol administration decreases phosphorylation of cyclic AMP response element-binding protein in granule cells of rat cerebellum

Journal of Neurochemistry
X YangG S Wand

Abstract

To help define the molecular basis of ethanol's actions on the nervous system, we have in previous studies demonstrated that ethanol administration triggers a robust increase in cyclic AMP-response element-binding protein (CREB) phosphorylation in the cerebellum. The purpose of the present study was to compare the effects of acute and chronic ethanol exposure on the phosphorylation of CREB in rat cerebellum and to determine which cell types in the cerebellum display this response to ethanol. An acute ethanol challenge (3.0 g/kg of body weight) induced a rapid increase in content of the phosphorylated form of CREB, peaking at 30 min and declining to basal levels within 2 h. Immunocytochemical studies revealed prominent ethanol-induced changes in phosphoCREB in the granule cell layer, with little phosphoCREB apparent in Purkinje cells. Following chronic ethanol exposure (5 weeks), induction of CREB phosphorylation by a subsequent acute ethanol challenge was markedly attenuated. The attenuation in CREB phosphorylation was associated with a significant reduction in the levels of the catalytic unit of protein kinase A and calcium/calmodulin-dependent protein kinase IV. In summary, induction of CREB phosphorylation in cerebellum is m...Continue Reading

Citations

Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Orna AsherIvan Diamond
Oct 31, 2002·The European Journal of Neuroscience·Barbara MontiAntonio Contestabile
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·J Hanoune, N Defer
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Sachin MoonatSubhash C Pandey
Mar 9, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alexandre E Medina
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Luli R AkinfiresoyeProsper N'Gouemo
Feb 17, 2005·Alcoholism, Clinical and Experimental Research·Subhash C PandeyFulton T Crews
Sep 15, 2000·Journal of Neurochemistry·P M FinkenstadtJ M Baraban
Aug 3, 2007·Journal of Neuroscience Research·Alexandre E Medina, Thomas E Krahe
Apr 26, 2006·Alcoholism, Clinical and Experimental Research·Roshani B CowmeadowNigel S Atkinson
Jun 10, 2009·Molecular Neurobiology·Jia Luo
Jul 5, 2003·The Journal of Biological Chemistry·Sajida HassanMichael F Miles

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