PMID: 8978717Jan 1, 1997Paper

Chronic ethanol administration regulates the expression of GABAA receptor alpha 1 and alpha 5 subunits in the ventral tegmental area and hippocampus

Journal of Neurochemistry
M E CharltonR S Duman

Abstract

Ethanol dependence and tolerance involve perturbation of GABAergic neurotransmission. Previous studies have demonstrated that ethanol treatment regulates the function and expression of GABAA receptors throughout the CNS. Conceivably, changes in receptor function may be associated with alterations of subunit composition. In the present study, a comprehensive (1-12 weeks) ethanol treatment paradigm was used to evaluate changes in GABAA receptor subunit expression in several brain regions including the cerebellum, cerebral cortex, ventral tegmental area (VTA) (a region implicated in drug reward/dependence), and the hippocampus (a region involved in memory/cognition). Expression of alpha 1 and alpha 5 subunits was regulated by ethanol in a region-specific and time-dependent manner. Following 2-4 weeks of administration, cortical and cerebellar alpha 1 and alpha 5 subunits immunoreactivity was reduced. In the VTA, levels of alpha 1 subunit immunoreactivity were significantly decreased after 12 weeks but not 1-4 weeks of treatment. Hippocampal alpha 1 subunit immunoreactivity and mRNA content were also significantly reduced after 12 but not after 4 weeks of treatment. In contrast, alpha 5 mRNA content was increased in this brain regi...Continue Reading

Citations

Nov 5, 2005·Alcoholism, Clinical and Experimental Research·Mridula RewalMarianna E Jung
Dec 24, 2005·Epilepsy Currents·Michael A Rogawski
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter W Kalivas, Charles O'Brien
Oct 16, 2015·Revista da Associação Médica Brasileira·João Victor Vezali CostardiSônia Valéria Pinheiro Malheiros
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Harry L JuneGregg E Homanics
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Tracy D StepanyanJohn M Littleton
Nov 26, 2014·Alcoholism, Clinical and Experimental Research·Samuel W CentanniH S Swartzwelder
Dec 17, 2019·Alcoholism, Clinical and Experimental Research·Paulina JaneczekJoanne M Lewohl
Feb 4, 2010·Pharmacological Reviews·Mikko Uusi-Oukari, Esa R Korpi
Dec 31, 2011·Human Genetics·Eric W KleeStephen C Ekker
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Mridula RewalJames W Simpkins
Jun 16, 2018·Trends in Pharmacological Sciences·Elif EnginUwe Rudolph
Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
Aug 26, 1998·Drug and Alcohol Dependence·M J Kreek, G F Koob
Apr 20, 2001·Brain Research. Molecular Brain Research·L M JohanekL K Vaughn
Apr 21, 1999·Brain Research. Brain Research Reviews·A K Mehta, M K Ticku
Sep 29, 2009·Pharmacology & Therapeutics·Leonardo PignataroNeil L Harrison

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