PMID: 8986236Dec 1, 1996Paper

Chronic ethanol consumption enhances endotoxin induced hepatic sinusoidal leukocyte adhesion

Alcoholism, Clinical and Experimental Research
E OhkiH Ishii

Abstract

In alcoholic liver disease, endotoxin has been postulated to play an important role in its pathogenesis. Endotoxin is known to lead to impediment of hepatic microcirculation, including the adhesion of leukocytes to sinusoidal endothelial cells. In this study, the effect of chronic ethanol consumption on the leukocyte adhesion elicited by endotoxin was examined. Male Wistar rats were pair-fed with a liquid diet containing ethanol or an isocaloric control diet for 6 weeks. The liver of anesthetized rats were placed on the nonfluorescent cover-glass for observation by an intravital inverted microscope equipped with a silicon intensified target camera. The red blood cell (RBC) velocity in hepatic sinusoids was measured by an off-line temporal correlation velocimeter (Capiflow, Sweden) after intravenous injection of fluorescein isothiocyanate-labeled rat RBC. RBC velocity in sinusoids was more severely disturbed in ethanol fed rats than in controls. Leukocytes were stained by the intravenous injection of carboxyfluorescein succinimidyl ester for a fluorographic observation of leukocyte adhesion. After lipopolysaccharide injection, the number of adherent leukocytes was significantly greater in ethanol-fed rats than in controls. Plasm...Continue Reading

References

Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AraiM Tsuchiya
Sep 1, 1985·Metabolism: Clinical and Experimental·J A SpitzerR E Fish
Mar 1, 1993·Immunology Today·C R Mackay, B A Imhof
Jan 16, 1998·Journal of Gastroenterology·Y HorieH Ishii

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Citations

Jul 31, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Y Horie, H Ishii
Apr 14, 2005·BMC Anesthesiology·Geoffrey M ThieleLynell W Klassen
May 2, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lutz SchneiderJens Werner
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A LawsonH Jaeschke
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·Y HorieH Ishii
Jun 1, 2000·Alcoholism, Clinical and Experimental Research·Y HorieH Ishii
Mar 17, 2004·The European Physical Journal. E, Soft Matter·Jun-Ichi FukudaHiroshi Yokoyama

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