Chronic ethanol consumption exacerbates liver injury following hemorrhagic shock: role of sinusoidal perfusion failure

Shock
I BauerM G Clemens

Abstract

Although the deleterious effect of chronic ethanol consumption on subsequent stressful events has long been recognized, the pathophysiological mechanisms are incompletely understood. This study tested whether chronic ethanol consumption in doses that increase sinusoidal contractility increases susceptibility to hepatic microvascular failure and liver injury after hemorrhagic shock. Liver microcirculation was assessed by in vivo microscopy during hemorrhage and up to 24 h after onset of resuscitation and was compared with liver histology and serum enzyme levels. Mean sinusoidal blood flow was neither impaired by chronic ethanol feeding at baseline nor during hemorrhage and early resuscitation. However, failure of individual sinusoids to conduct flow was observed more frequently after fluid resuscitation in ethanol-fed animals (e.g. at 1 h after onset of volume therapy: 26% of sinusoids) than in controls (11%), reflecting substantial flow heterogeneity. Failing sinusoids had substantially smaller diameters than sinusoids conducting flow with a more profound and sustained response in ethanol-fed rats. At 24 h marked pericentral necrosis and increase in serum alanine aminotransferase levels were observed in six of nine surviving et...Continue Reading

Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B H PannenK K Geiger
Jun 9, 2005·The Journal of Surgical Research·Yukihiro YokoyamaIrshad H Chaudry
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BauerM G Clemens
Aug 25, 2006·Journal of Gastroenterology and Hepatology·Yukihiro YokoyamaJian X Zhang
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Willson KwokMark G Clemens
May 29, 2002·Anesthesia and Analgesia·Benedikt H J Pannen
Nov 11, 2014·Hepatology International·Sreetha Sidharthan, Shyam Kottilil
Mar 8, 2006·Critical Care Medicine·Rene SchmidtBenedikt H J Pannen
Nov 23, 2006·The Surgical Clinics of North America·Vishal Bansal, Vaishali Dixit Schuchert
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Walid S KamounMark G Clemens
Aug 18, 2004·The Journal of Surgical Research·Yukihiro YokoyamaIrshad H Chaudry
Mar 17, 2009·Biochemical and Biophysical Research Communications·Ying-Ying YangShou-Dong Lee
Aug 2, 2005·Alcohol·Iain H McKillop, Laura W Schrum
Jul 1, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G A WannerW Ertel
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Y HanH Ishii
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B H PannenK K Geiger
Jun 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus PaxianMark G Clemens

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