Chronic ethanol intake and ageing effects on cortical and basal forebrain cholinergic parameters: morphometric and biochemical studies

Addiction Biology
Paula A FernandesJosé E H Pittella

Abstract

Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of choline acetyltransferase-immunoreactive cholinergic neurons was determined in adjacent sections. Acetylcholine release and choline-acetyltransferase activity in the cerebral cortex were assessed in the same animals. Nutritional parameters of the ethanol treated animals were monitored and found to be normal. Chronic exposure to ethanol did not result in global neuronal loss or loss of cholinergic neurons in the basal nucleus region. However, a greater expression of ChAT-immunoreactivity in the basal nucleus region and a tendency toward increased ChAT activity in the cerebral cortex of the control and treated aged animals, compared respectively to adult ones, were observed. These findings suggest adaptive changes of the aged rats in response to the possible cholinergic hypofunction, manifested as a decreased release of acetylcholine under stimulated conditions.

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Citations

Jun 24, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Bjarne ElholmUlrik Becker
Mar 19, 2011·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Bjarne ElholmUlrik Becker
May 8, 2015·The Journal of Nursing Education·Rebecca Schnall
Apr 13, 2017·Alcoholism, Clinical and Experimental Research·Christopher W KahlerStephanie S O'Malley
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May 15, 2003·British Journal of Pharmacology·Hui-Fang Li, Joan J Kendig

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