PMID: 22580523May 15, 2012Paper

Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line

Pharmacological Reports : PR
W Dyr, Ewa Taracha

Abstract

The development of tolerance to alcohol with chronic consumption is an important criterion for an animal model of alcoholism and may be an important component of the genetic predisposition to alcoholism. The aim of this study was to determine whether the selectively bred Warsaw High Preferring (WHP) line of alcohol-preferring rats would develop behavioral and metabolic tolerance during the free-choice drinking of ethanol. Chronic tolerance to ethanol-induced sedation was tested. The loss of righting reflex (LRR) paradigm was used to record sleep duration in WHP rats. Ethanol (EtOH)-naive WHP rats received a single intraperitoneal (i.p.) injection of 5.0 g ethanol/kg body weight (b.w.), and sleep duration was measured. Subsequently, rats had access to a 10% ethanol solution under a free-choice condition with water and food for 12 weeks. After 12 weeks of the free-choice intake of ethanol, the rats received another single i.p. injection of 5.0 g ethanol/kg b.w., and sleep duration was reassessed. The blood alcohol content (BAC) for each rat was determined after an i.p. injection of 5 g/kg of ethanol in naive rats and again after chronic alcohol drinking at the time of recovery of the righting reflex (RR). The results showed that ...Continue Reading

References

Jan 1, 1979·Drug and Alcohol Dependence·T K LiM B Waller
May 1, 1992·Trends in Pharmacological Sciences·H H Samson, R A Harris
Jan 1, 1991·Biology of the Cell·E E Baulieu
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·K Kiianmaa
Mar 31, 1989·Science·D M LovingerF F Weight
Mar 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·G SlamaF Dauchy
Jan 1, 1989·Molecular Neurobiology·M Schumacher, B S McEwen
Nov 1, 1988·Journal of Analytical Toxicology·L SerranoF Quattrocchi
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·E L Morrow, V G Erwin
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·G J GattoT K Li
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·D Lester, E X Freed
Jan 1, 1980·Acta Psychiatrica Scandinavica. Supplementum·B TabakoffP L Hoffman
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·J M KhannaH Kalant
Jul 1, 1997·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·G Colombo
Jul 22, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C J SlaweckiC L Ehlers
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·A D Barbosa, G S Morato
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·T E ThieleR D Palmiter
Dec 1, 2001·European Journal of Pharmacology·A D Barbosa, G S Morato
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Nicholas W GilpinNancy E Badia-Elder
Jun 18, 2004·Alcoholism, Clinical and Experimental Research·M M Silveri, L P Spear
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Jon R FeeTodd E Thiele
May 5, 2005·The European Journal of Neuroscience·Andrea CippitelliUNKNOWN European TARGALC Consortium
Oct 24, 2006·Neurotoxicology and Teratology·Elena I Varlinskaya, Linda P Spear

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Citations

Oct 23, 2013·Pharmacological Reports : PR·Ewa IgnatowiczEwa Florek
Jul 25, 2019·Frontiers in Neurology·Liubov S KalinichenkoChristian P Müller

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