Addictions, including alcohol use disorders, are characterized by the loss of control over drug seeking and consumption, but the neural circuits and signaling mechanisms responsible for the transition from controlled use to uncontrolled abuse remain incompletely understood. Prior studies have shown that 'compulsive-like' behaviors in rodents, for example, persistent responding for ethanol (EtOH) despite punishment, are increased after chronic exposure to EtOH. The main goal of the current study was to assess the effects of chronic intermittent EtOH (CIE) exposure on multiple, putative measures of compulsive-like EtOH seeking in C57BL/6 J mice. Mice were exposed to two or four weekly cycles of CIE and then, post-withdrawal, tested for progressive ratio responding for EtOH, sustained responding during signaled EtOH unavailability and (footshock) punished suppression of responding for EtOH. Results showed that mice exposed to CIE exhibited attenuated suppression of EtOH seeking during punishment, as compared with air-exposed controls. By contrast, CIE exposure affected neither punished food reward-seeking behavior, nor other putative measures of compulsive-like EtOH seeking. Ex vivo reverse transcription polymerase chain reaction ...Continue Reading
Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain
Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure
Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
A temporal threshold for induction of persistent alcohol preference: behavioral evidence in a rat model of intermittent intoxication
Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis
Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice
Chronic intermittent ethanol exposure enhances NMDA-receptor-mediated synaptic responses and NMDA receptor expression in hippocampal CA1 region
Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice
Effect of duration and pattern of chronic ethanol exposure on tolerance to the discriminative stimulus effects of ethanol in C57BL/6J mice
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens
Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice
Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration
N-methyl-D-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure
Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol
In vivo chronic intermittent ethanol exposure reverses the polarity of synaptic plasticity in the nucleus accumbens shell
Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice
Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats
Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice
The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice
Repeated episodes of chronic intermittent ethanol promote insensitivity to devaluation of the reinforcing effect of ethanol
Integrated circuits and molecular components for stress and feeding: implications for eating disorders
KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction
Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats
Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking
Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective
Loss of control over alcohol seeking in rats depends on individual vulnerability and duration of alcohol consumption experience
Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice
Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study
Female Rodents Yield New Insights into Compulsive Alcohol Use and the Impact of Dependence: Commentary on Xie et al., 2019, "Sex Differences in Ethanol Reward Seeking Under Conflict in Mice"
Aberrant insular cortex connectivity in abstinent alcohol-dependent rats is reversed by dopamine D3 receptor blockade
Additive influences of acute early life stress and sex on vulnerability for aversion-resistant alcohol drinking
Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression
Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats.
Increased Synaptic Strength and mGlu2/3 Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol.
The contribution of medium spiny neuron subtypes in the nucleus accumbens core to compulsive-like ethanol drinking.
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This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.
Alcohol Use Disorder
Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.