PMID: 15376671Sep 21, 2004Paper

Chronic excitotoxicity in the guinea pig cochlea induces temporary functional deficits without disrupting otoacoustic emissions

The Journal of the Acoustical Society of America
Colleen G Le PrellDavid B Moody

Abstract

Brief cochlear excitotoxicity produces temporary neural swelling and transient deficits in auditory sensitivity; however, the consequences of long-lasting excitotoxic insult have not been tested. Chronic intra-cochlear infusion of the glutamate agonist AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) resulted in functional deficits in the sound-evoked auditory brainstem response, as well as in behavioral measures of hearing. The electrophysiological deficits were similar to those observed following acute infusion of AMPA into the cochlea; however, the concentration-response curve was significantly shifted as a consequence of the slower infusion rate used with chronic cochlear administration. As observed following acute excitotoxic insult, complete functional recovery was evident within 7 days of discontinuing the AMPA infusion. Distortion product otoacoustic emissions were not affected by chronic AMPA infusion, suggesting that trauma to outer hair cells did not contribute to AMPA-induced deficits in acoustic sensitivity. Results from the current experiment address the permanence of deficits induced by chronic (14 day) excitotoxic insult as well as deficits in psychophysical detection of longer duration acoustic signals.

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Citations

Mar 1, 2005·Journal of the Association for Research in Otolaryngology : JARO·Colleen G Le PrellSanford C Bledsoe
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Jun 29, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Colleen G Le PrellPeter A Boxer
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Dec 5, 2019·The Journal of the Acoustical Society of America·Gaëlle NaertColleen G Le Prell
Dec 23, 2016·Hearing Research·Megan KobelJianxin Bao

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