PMID: 8444718Jan 1, 1993Paper

Chronic exercise enhances in vivo and in vitro cytotoxic mechanisms of natural immunity in mice

Journal of Applied Physiology
B MacNeil, L Hoffman-Goetz

Abstract

This study investigated the influence of 9 wk of chronic exercise on natural cytotoxicity in male C3H mice. Both in vivo cytotoxicity (pulmonary vasculature) and in vitro cytotoxicity (spleen) were determined for voluntary (wheel running; n = 30) and forced (treadmill running, 15 m/min, 30 min/day; n = 30) exercise protocols. A sedentary control group (n = 30) and a treadmill control group (5 m/min, 5 min/day; n = 30) were also included. After 9 wk of chronic exercise, submaximal exercise O2 uptake was reduced in the wheel-running group relative to that in sedentary or treadmill-trained mice. Maximal citrate synthase activity of soleus muscle was higher in treadmill-trained group compared with that in sedentary or wheel-running mice. Chronic exercise consistently reduced percent retention of CIRAS 3 tumor cells in the lungs of treadmill- (15.3 +/- 1.4) and wheel- (17.9 +/- 1.4) trained mice below that of sedentary (29.5 +/- 2.7) and treadmill control (25.8 +/- 1.8) groups (P < 0.001). Injection of anti-asialo GM1 (ASGM1) antibody increased tumor cell retention in the lungs for all groups but did not alter the differences between activity conditions. In vitro cytotoxicity was enhanced in treadmill- and wheel-trained mice relativ...Continue Reading

Citations

Mar 1, 1996·Clinical & Experimental Metastasis·L Jadeski, L Hoffman-Goetz
Jul 14, 2000·Physiological Reviews·B K Pedersen, L Hoffman-Goetz
May 15, 2003·Physiological Genomics·Daniel Bernstein
Jan 6, 2005·Medicine and Science in Sports and Exercise·Sarah L KennedyMonika Fleshner
Nov 5, 2005·American Journal of Epidemiology·Sai Yi PanUNKNOWN Canadian Cancer Registries Epidemiology Research Group
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Feb 2, 1999·Medicine and Science in Sports and Exercise·J A WoodsD C Nieman
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Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·L Hoffman-Goetz, J Husted
Jun 5, 1998·The American Journal of Physiology·J M DavisA Ghaffar
Dec 25, 2007·The Journal of Nutrition·Connie J RogersStephen D Hursting
Jun 24, 2010·The Proceedings of the Nutrition Society·J RomeoA Marcos
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Jun 26, 2007·Journal of Immunotherapy·Noa Benaroya-MilshteinNurit Hollander
Jun 11, 2011·Journal of Hypertension·Julie L Lavoie, Jolanta Gutkowska
Apr 12, 2008·Journal of Applied Physiology·Peter T CampbellCornelia M Ulrich
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Nov 20, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Masateru UchiyamaMasanori Niimi
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