Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue

Frontiers in Physiology
Natalia de Las HerasAlmudena Gómez-Hernández

Abstract

The aim of the present work was to study the consequences of chronic exercise training on factors involved in the regulation of mitochondrial remodeling and biogenesis, as well as the ability to produce energy and improve insulin sensitivity and glucose uptake in rat brown adipose tissue (BAT). Male Wistar rats were divided into two groups: (1) control group (C; n = 10) and (2) exercise-trained rats (ET; n = 10) for 8 weeks on a motor treadmill (five times per week for 50 min). Exercise training reduced body weight, plasma insulin, and oxidized LDL concentrations. Protein expression of ATP-independent metalloprotease (OMA1), short optic atrophy 1 (S-OPA1), and dynamin-related protein 1 (DRP1) in BAT increased in trained rats, and long optic atrophy 1 (L-OPA1) and mitofusin 1 (MFN1) expression decreased. BAT expression of nuclear respiratory factor type 1 (NRF1) and mitochondrial transcription factor A (TFAM), the main factors involved in mitochondrial biogenesis, was higher in trained rats compared to controls. Exercise training increased protein expression of sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) and AMP-activated protein kinase (pAMPK/AMPK ratio) in BAT. In addition, training i...Continue Reading

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Citations

Jul 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yee Kit TaiAlfredo Franco-Obregón
May 16, 2020·Frontiers in Endocrinology·Pablo Vidal, Kristin I Stanford
Feb 15, 2019·Biology·Carmem Peres Valgas da SilvaKristin I Stanford
May 20, 2021·Mitochondrion·S S MichurinaYe V Parfyonova
Nov 23, 2021·Pflügers Archiv : European journal of physiology·Natalia de Las Heras, Vicente Lahera

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Methods Mentioned

BETA
electrophoresis
immunoprecipitation
immunoprecipitations

Software Mentioned

GraphPad
GraphPad Prism

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