Chronic exogenous hyperinsulinemia in pregnancy: a rat model of pregnancy-induced hypertension.

Journal of the American Society of Nephrology : JASN
Eduardo PodjarnyM Bursztyn

Abstract

Insulin resistance and hyperinsulinemia are associated with essential hypertension. There is also evidence of hyperinsulinemia in women who developed hypertension in pregnancy (P). The present study examines whether chronic hyperinsulinemia in pregnant rats plays a role in the development of hypertension in pregnancy. A sustained-release insulin pellet was implanted subcutaneously in 15 Wistar rats (P-INS) 1 wk before and on day 7 of pregnancy; 14 control rats were sham-implanted (P-SHAM). Tail-cuff systolic BP (SBP), serum triglycerides, glucose, insulin, renal function, and urinary excretion of Na+ and of metabolites of nitric oxide were determined throughout pregnancy. Data were analyzed by ANOVA with basal body weight as covariate analysis of covariance. Results are expressed as the mean +/- SD. Body weight; water and food intake; urine volume; creatinine clearance; and level of proteinuria at the end of pregnancy were similar in both groups. The number of fetuses was 9 +/- 2.3 in P-INS versus 11 +/- 2.4 in pregnant control rats (P < 0.05). Before mating, SBP was similar, but at the end of pregnancy SBP was 110 +/- 18 mmHg in P-INS versus 85 +/- 12 mmHg in pregnant rats (P < 0.05). Serum triglycerides and Na+ were also high...Continue Reading

Citations

May 4, 1999·Clinical and Experimental Pharmacology & Physiology·R KomersL Kazdová
Apr 1, 1999·Annual Review of Physiology·M F Romero, W F Boron
Mar 5, 2003·Advances in Renal Replacement Therapy·Chris Baylis
Oct 24, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Michael BursztynJacques Bernheim
Oct 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·J VanderlelieA V Perkins
Jan 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal Y AntebyIlana Ariel
Jul 27, 2006·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Jessica J Vanderlelie, Anthony V Perkins
Apr 2, 1999·Seminars in Perinatology·E PodjarnyG Losonczy
Nov 1, 2008·Diabetes/metabolism Research and Reviews·Kazuhiro SugimotoMinoru Yasujima
Apr 19, 2011·Placenta·F P McCarthyS K Walsh
Sep 16, 2011·American Journal of Hypertension·Mogher KhamaisiMichael Bursztyn

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