Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate

Clinical Kidney Journal
Soisungwan SatarugDavid A Vesey

Abstract

Urinary 20-hydroxyeicosatetraenoic acid (20-HETE) has been associated with hypertension in women with elevated urinary cadmium (Cd) excretion rates. The present study investigates the urinary Cd and 20-HETE levels in relation to the estimated glomerular filtration rate (eGFR) and albumin excretion in men and women. A population-based, cross-sectional study, which included 225 women and 84 men aged 33-55 years, was conducted in a rural area known to be polluted with Cd. In all subjects, lower eGFR values were associated with higher urinary Cd excretion (P = 0.030), and tubulopathy markers N-acetyl-β-d-glucosaminidase (P < 0.001) and β2-microglobulin (β2-MG) (P < 0.001). On average, the hypertensive subjects with the highest quartile of urinary Cd had eGFR values of 12 and 17 mL/min/1.73 m2 lower than that in the hypertensive (P = 0.009) and normotensive subjects (P < 0.001) with the lowest quartile of urinary Cd, respectively. In men, urinary albumin was inversely associated with 20-HETE (β = -0.384, P < 0.001), while showing a moderately positive association with systolic blood pressure (SBP) (β = 0.302, P = 0.037). In women, urinary albumin was not associated with 20-HETE (P = 0.776), but was associated with tubulopathy, refle...Continue Reading

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Citations

Mar 7, 2020·Toxics·Soisungwan SatarugDavid A Vesey
Oct 23, 2019·Toxics·Soisungwan SatarugKenneth R Phelps
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps
Aug 29, 2020·The Science of the Total Environment·Yu-Mei HsuehChi-Jung Chung
Jan 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ivana MirkovMilena Kataranovski
Feb 14, 2021·International Journal of Molecular Sciences·Soisungwan SatarugKenneth R Phelps
May 16, 2021·Environmental Science and Pollution Research International·Laorrat PhuapittayalertNatthiya Sakulsak
May 31, 2021·International Journal of Hygiene and Environmental Health·Xiao ChenTaiyi Jin
Nov 14, 2021·International Archives of Occupational and Environmental Health·Victor O MartinezJosé A Menezes-Filho

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Methods Mentioned

BETA
urine collection

Software Mentioned

SPSS

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